Results 231 to 240 of about 431,385 (241)

Natural modulators of liver X receptors

Journal of Integrative Medicine, 2014
Nuclear receptor transcription factors are ligand-activated proteins that control various biological events from cell growth and development to lipid metabolism, and energy and glucose homeostasis. Nuclear receptors are important drug targets for metabolic diseases. Liver X receptors (LXRs) are nuclear receptor transcription factors that play essential
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Enolase is regulated by Liver X Receptors

Steroids, 2015
Enolase is a glycolytic enzyme known to inhibit cholesteryl ester hydrolases (CEHs). Cholesteryl ester loading of macrophages, as occurs during atherosclerosis, is accompanied by increased Enolase protein and activity. Here, we describe that J774 macrophages treated with LXR agonists exhibit reduced Enolase transcript and protein abundance.
de Boussac, Hugues, Maqdasy, Salwan, Trousson, Amalia, Zelcer, Noam, Volle, H., Lobaccaro, A., Baron, Silvere   +6 more
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International Union of Pharmacology. LXII. The NR1H and NR1I Receptors: Constitutive Androstane Receptor, Pregnene X Receptor, Farnesoid X Receptor α, Farnesoid X Receptor β, Liver X Receptor α, Liver X Receptor β, and Vitamin D Receptor

Pharmacological Reviews, 2006
The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and ...
David D, Moore, Shigeaki, Kato, Wen, Xie, David J, Mangelsdorf, Daniel R, Schmidt, Rui, Xiao, Steven A, Kliewer   +6 more
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Liver X Receptors

Cardiology in Review, 2010
Liver X receptors (LXRs) are nuclear receptors that play a major role in the expression of genes which are involved in lipid metabolism. LXRs are part of the superfamily of steroid receptors that work to deliver metabolic signals on the transcriptional level to either suppress or activate target genes.
Neil, Parikh, William H, Frishman
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The liver X receptors.

Current opinion in investigational drugs (London, England : 2000), 2005
The liver X receptors (LXRs), members of the nuclear receptor superfamily, are potential targets for a variety of diseases. While there are many opportunities for the development of LXR-based therapeutics, there are some major hurdles, such as the ability of LXRs to cause hypertriglyceridemia, as well as some species-dependent aspects of LXR-mediated ...
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Liver X Receptors

Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents, 2002
Xiao Hu, Deepak Lala
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Limonoids as liver X receptor modulators

2022
Atherosklerotische Herz-Kreislauf-Erkrankungen verursachen klinische Endpunkte wie den Myokardinfarkt und Schlaganfall und stellen somit die häufigste Todesursache weltweit dar. Der Liver X Rezeptor (LXR) übernimmt eine Vielzahl an regulatorischen Aufgaben im Cholesterinmetabolismus und eignet sich deshalb als ein ausgezeichnetes Target in der ...
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Liver X receptors and atherosclerosis.

IDrugs : the investigational drugs journal, 2004
Cardiovascular disease, the primary cause of death and illness in the industrialized world, is typically due to complications of atherosclerosis, a multifactorial disease of the arterial intima. The liver X receptors (LXRs), LXRalpha and LXRbeta, are intracellular receptors that appear to play an important role in protection against atherosclerosis ...
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Liver X Receptors in Bacterial Clearance

Science's STKE, 2004
Liver X receptors (LXRs) are well known for acting as heterodimers with retinoid X receptors (RXRs) to regulate the expression of genes involved in lipid metabolism. Joseph et al . expand the role of the LXRα isoform to include regulation of susceptibility to bacterial infection.
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[Recent advances on liver X receptors].

Sheng li ke xue jin zhan [Progress in physiology], 2012
The liver X receptors (LXRs), that are nuclear receptors activated by oxysterols, play central roles in the transcriptional control of cholesterol metabolism and function as the sensors of cholesterol homeostasis. In addition, LXRs have also been found to modulate lipogenesis, carbohydrate metabolism, innate immune and inflammatory responses in ...
Qiang, Wang, Yu, Jiang
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