Results 21 to 30 of about 520,167 (196)
Molecules, 2022 Background: Unwanted drug-drug interactions (DDIs), as caused by the upregulation of clinically relevant drug metabolizing enzymes and transporter proteins in intestine and liver, have the potential to threaten the therapeutic efficacy and safety of ...
Christoph Wenzel +6 more
doaj +1 more source
Liver X receptor in cholesterol metabolism [PDF]
Journal of Endocrinology, 2009 The liver X receptors (LXRs) are nuclear receptors that are activated by endogenous oxysterols, oxidized derivatives of cholesterol. There are two isoforms of LXR, LXRα (NR1H3) and LXRβ (NR1H2). Both LXRα and LXRβ regulate gene expression by binding to DNA sequences associated with target genes as heterodimers with isoforms of the retinoid X receptor ...
Chunyan, Zhao, Karin, Dahlman-Wright
openaire +2 more sources
Inflammation Triggers Liver X Receptor-Dependent Lipogenesis [PDF]
Molecular and Cellular Biology, 2020 Immune cell function can be modulated by changes in lipid metabolism. Our studies indicate that cholesterol and fatty acid synthesis increases in macrophages between 12 and 18 h after the activation of Toll-like receptors with proinflammatory stimuli and that the upregulation of lipogenesis may contribute to the resolution of inflammation.
Sophie R. Liebergall +7 more
openaire +2 more sources
Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. [PDF]
, 2016 Liver X receptors (LXRs) are transcriptional regulators of cellular and systemic cholesterol homeostasis. Under conditions of excess cholesterol, LXR activation induces the expression of several genes involved in cholesterol efflux, facilitates ...
Casero, David +13 more
core +2 more sources
Phosphorylation of the liver X receptors [PDF]
FEBS Letters, 2006 The liver X receptors (LXRs) function as nutritional sensors for cholesterol and have important roles in lipid metabolism, glucose homeostasis, and inflammation. We provide the first evidence that LXRs are phosphorylated proteins. Mutational analysis and metabolic labeling indicate LXRα is phosphorylated on serine 198 in the hinge region.
Chen, Mingyi +3 more
openaire +2 more sources
Nuclear receptors in neurodegenerative diseases
Neurobiology of Disease, 2014 Nuclear receptors have generated substantial interest in the past decade as potential therapeutic targets for the treatment of neurodegenerative disorders.
Rebecca Skerrett +2 more
doaj +1 more source
Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profiling. [PDF]
, 2012 BackgroundRetinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated from wild type and RXRα-null mouse ...
Fang, Jianwen +5 more
core +2 more sources
Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR [PDF]
, 2014 The nuclear receptors CAR (constitutive androstane receptor) and possibly PXR (pregnane X receptor) mediate the hepatic effects of phenobarbital (PB) and similar-acting compounds.
Braeuning, Albert +5 more
core +2 more sources
Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease [PDF]
The Korean Journal of Internal Medicine, 2019 Background/Aims Intestinal cholesterol absorption includes intestinal Niemann-Pick C1-like 1 (NPC1L1) and is an important target pathway in nonalcoholic fatty liver disease (NAFLD).
Sang Bong Ahn +4 more
doaj +1 more source
Effect of antiandrogen flutamide on measures of hepatic regeneration in rats [PDF]
, 1989 Male rat liver undergoes a process of demasculinization during hepatic regeneration following partial hepatectomy. The possibility that antiandrogens might potentiate this demasculinization process and in so doing augment the hepatic regenerative ...
A Francavilla +36 more
core +1 more source