Results 31 to 40 of about 520,167 (196)

Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement [PDF]

, 2015
Hepatocellular carcinoma (HCC) is the most common malignancy of the liver and the third cause of cancer death worldwide. Chronic hepatitis due to HBV and HCV infection are two major risk factors for HCC worldwide.
Cuestas, María Luján, Mathet, Veronica Lidia, Oubiña, Jose Raul   +2 more
core   +1 more source

Pharmacophore modeling for biological targets with high flexibility: LXRβ case study

Medicine in Drug Discovery, 2022
Many biological targets are characterized by high binding pocket flexibility posing a challenge in identifying important ligand binding features. Liver X receptors (LXRs) are members of the nuclear hormone receptor super family.
Sophia Kchouk, Lamees Hegazy
doaj   +1 more source

Metabolic interactions between vitamin A and conjugated linoleic acid [PDF]

, 2014
Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner.
BANNI, SEBASTIANO, Belury, MA, CARTA, GIANFRANCA, Cordeddu, L, Giordano, E, MURRU, MARIA ELISABETTA, Ortiz, B, Quadro, L   +7 more
core   +2 more sources

Endocannabinoid-related compounds in gastrointestinal diseases [PDF]

, 2018
The endocannabinoid system (ECS) is an endogenous signalling pathway involved in the control of several gastrointestinal (GI) functions at both peripheral and central levels.
Alessandra, D'Alessandro, Esposito, Giuseppe, Gigli, Stefano, Giovanni, Sarnelli, Marcella, Pesce, Osvaldo, Borrelli, Rosario, Cuomo, Seguella, Luisa   +7 more
core   +1 more source

Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics

Cells, 2020
Autophagy is an intracellular process that targets intracellular pathogens for lysosomal degradation. Autophagy is tightly controlled at transcriptional and post-translational levels.
Prashanta Silwal, Seungwha Paik, Sang Min Jeon, Eun-Kyeong Jo   +3 more
doaj   +1 more source

Liver X Receptor Regulation of Glial Cell Functions in the CNS

Biomedicines, 2022
In this review, we discuss the role of liver X receptors (LXRs) in glial cells (microglia, oligodendrocytes and astrocytes) in the central nervous system (CNS).
Xiaoyu Song, Wanfu Wu, Margaret Warner, Jan-Åke Gustafsson   +3 more
doaj   +1 more source

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +3 more sources

The nuclear receptor FXR, but not LXR, up-regulates bile acid transporter expression in non-alcoholic fatty liver disease

Annals of Hepatology, 2015
Background. Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. Patients with non-alcoholic steatohepatitis (NASH) have increased plasmatic and hepatic concentrations of bile acids (BA), suggesting that they can ...
Nancy E. Aguilar-Olivos, Daniel Carrillo-Córdova, Jesús Oria-Hernández, Vicente Sánchez-Valle, Guadalupe Ponciano-Rodríguez, Manuel Ramírez-Jaramillo, Fredy Chablé-Montero, Norberto C. Chávez-Tapia, Misael Uribe, Nahum Méndez-Sánchez, MD, MSc, PhD, FACG, AGAF   +9 more
doaj   +1 more source

Bile Acids in Autoimmune Liver Disease: Unveiling the Nexus of Inflammation, Inflammatory Cells, and Treatment Strategies

Cells, 2023
As bile acids not solely play an essential role in nutrition absorption, but also in regulating metabolic functions as well as immune response, bile acids and their signaling pathways are increasingly acknowledged as potential therapeutic targets in the ...
Tianhao Zhou, AbdiGhani Ismail, Heather Francis   +2 more
doaj   +1 more source

Melatonin receptor expression in the zebra finch brain and peripheral tissues [PDF]

, 2012
The circadian endocrine hormone melatonin plays a significant role in many physiological processes such as modulating sleep/wake cycle and oxidative stress.
Brandstaetter, Roland, Helfer, Gisela, Jones, Catherine   +2 more
core   +1 more source