Results 51 to 60 of about 524,130 (286)
Brain cholesterol in normal and pathological aging
Oléagineux, Corps gras, Lipides, 2011 Aberrations in cerebral cholesterol homeostasis can lead to severe neurological diseases. Recent findings strengthen the link between brain cholesterol metabolism and factors involved in synaptic plasticity, a process essential for learning and memory ...
Vanmierlo Tim +2 more
doaj +1 more source
Corepressor diversification by alternative mRNA splicing is species specific. [PDF]
, 2016 BackgroundSMRT and NCoR are corepressor paralogs that help mediate transcriptional repression by a variety of transcription factors, including the nuclear hormone receptors.
Goodson, Michael L +2 more
core +2 more sources
Journal of Pharmacological Sciences, 2005 Nuclear receptors are ligand-dependent transcription factors that recently have been shown to play important roles in the metabolism of cholesterol and bile acids.
Makoto Makishima
doaj +1 more source
LXR agonist improves peripheral neuropathy and modifies PNS immune cells in aged mice
Journal of Neuroinflammation, 2022 Background Peripheral neuropathy is a common and progressive disorder in the elderly that interferes with daily activities. It is of importance to find efficient treatments to treat or delay this age-related neurodegeneration.
Chaitanya K. Gavini +5 more
doaj +1 more source
Bile acids as global regulators of hepatic nutrient metabolism
Liver Research, 2017 Bile acids (BA) are synthesized from cholesterol in the liver. They are essential for promotion of the absorption of lipids, cholesterol, and lipid-soluble vitamins from the intestines.
Phillip B. Hylemon +4 more
doaj +1 more source
Regenerating Rat Liver: Correlations Between Estrogen Receptor Localization and Deoxyribonucleic Acid Synthesis [PDF]
, 1984 Estrogen receptor activity was quantitated in the cytosol and nucleus of normal rat liver and in regenerating rat liver at several time intervals after 75% hepatectomy. Cytosolic estradiol binding in regenerating liver decreases at 12, 24, and 48 h after
Di Leo, A +6 more
core +1 more source
Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. [PDF]
, 2018 Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models.
Bahadorani, John +16 more
core +1 more source
Liver X receptors and fat cell metabolism [PDF]
International Journal of Obesity, 2012 Liver X receptors (LXRs) are members of the nuclear receptor family and are present in two isoforms, α and β, encoded by two separate genes. Originally described in the liver, LXRs have in the last 15 years been implicated in central metabolic pathways, including bile acid synthesis, lipid and glucose homeostasis.
Laurencikiene, J, Rydén, M
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Gastrointestinal graft‐versus‐host disease (GI GVHD) following hematopoietic stem cell transplant is typically managed with medical therapy, but surgery and angioembolization may be warranted in selected cases with life‐threatening complications.
Gaia Brunetti +12 more
wiley +1 more source
Ligand specificity and evolution of liver X receptors [PDF]
The Journal of Steroid Biochemistry and Molecular Biology, 2008 Liver X receptors (LXRs) are key regulators of lipid and cholesterol metabolism in mammals. Little is known, however, about the function and evolution of LXRs in non-mammalian species. The present study reports the cloning of LXRs from African clawed frog (Xenopus laevis), Western clawed frog (Xenopus tropicalis), and zebrafish (Danio rerio), and their
Erica J, Reschly +5 more
openaire +2 more sources