Results 71 to 80 of about 520,167 (196)

Liver X Receptors and Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2014
A critical event in the development of atherosclerosis is the recruitment of macrophages to the underlying epithelial layer of blood vessel walls and the uncontrolled uptake of oxidized/modified cholesterol. Continued accumulation of oxidized/modified cholesterol by macrophages and an associated inflammatory response leads to foam cell formation and ...
Irena D, Ignatova, Ira G, Schulman
openaire   +2 more sources

PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis

Journal of Lipid Research, 2004
The nuclear receptor superfamily is composed of transcription factors that positively and negatively regulate gene expression in response to the binding of a diverse array of lipid-derived hormones and metabolites.
Andrew C. Li, Christopher K. Glass
doaj   +1 more source

Regulation of 3β-Hydroxysteroid Dehydrogenase/∆5-∆4 Isomerase: A Review [PDF]

, 2013
This review focuses on the expression and regulation of 3β-hydroxysteroi ddehydrogenase/Δ5-Δ4 isomerase (3β-HSD), with emphasis on the porcine version. 3β-HSD is often associated with steroidogenesis, but its function in the metabolism of both steroids ...
Abbaszade, Banner, Belanger, Beltowski, Benton, Berchtold, Bo Ekstrand, Brunius, Catalfo, Chapman, Chedrese, Chen, Chen, Cherradi, Clark, Coniglio, Conley, Conley, Conley, Cooke, Couet, Coulter, Cue, Davis, De Launoit, Doran, Doran, Dorgan, Dupont, Fink-Gremmels, Furster, Furster, Galarreta, Galia Zamaratskaia, Garrett, Garrett, Gingras, Gingras, Gromadzka-Ostrowska, Haider, Hassan, Havelock, Headon, Hierlihy, Hild-Petito, Hoog, Hu, Joernvall, Kallberg, Kaynard, Keeney, Keeney, Kershaw, Kiessling, Kostic, Kozlowska, Kumar, Labelle-Dumais, Labrie, LaVoie, Leers-Sucheta, Li, Liang, Lorence, Majdic, Martin, Martin Rasmussen, Mason, Mason, Matsunaga, Mcallister, Meadus, Mizrachi, Mode, Mullany, Nakajin, Nakamura, Naville, Nicolau-Solano, Papacleovoulou, Park, Payne, Payne, Payne, Pelletier, Penning, Picon, Rasmussen, Rasmussen, Rasmussen, Rasmussen, Saez, Samuels, Sasano, Sauer, Shapiro, Siiteri, Simard, Simard, Sirianni, Sordoillet, Stayrook, Sun, Suzuki, Takikawa, Takikawa, Tang, The, Tomankova, Tremblay, Val, Von Teichman, Walstra, Wang, Waxman, Waxman, Wong, Yuan, Zamaratskaia, Zamaratskaia, Zhao, Zinedine   +121 more
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Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B−/− (Wilson disease) mice [PDF]

Hepatology, 2016
Wilson disease (WD) is a hepatoneurological disorder caused by mutations in the copper‐transporter, ATP7B. Copper accumulation in the liver is a hallmark of WD. Current therapy is based on copper chelation, which decreases the manifestations of liver disease, but often worsens neurological symptoms. We demonstrate that in Atp7b−/−
James P, Hamilton, Lahari, Koganti, Abigael, Muchenditsi, Venkata S, Pendyala, David, Huso, Joseph, Hankin, Robert C, Murphy, Dominik, Huster, Uta, Merle, Christopher, Mangels, Nan, Yang, James J, Potter, Esteban, Mezey, Svetlana, Lutsenko   +13 more
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Effects of Resveratrol Supplementation and Exercise on Apoptosis, Lipid Profile, and Expression of Farnesoid X Receptor, Liver X Receptor and Sirtuin 1 Genes in the Liver of Type 1 Diabetic Rats

Medical Laboratory Journal, 2022
Background and objectives: Diabetes mellitus is the most common metabolic disorder in the world. Here, we evaluated effects of resveratrol supplementation alone and combined with exercise on blood glucose, insulin, lipid profile, apoptosis biomarkers ...
Ali Nouri, Parvin Farzanegi, Mohammad Ali Azarbayjani   +2 more
doaj  

Anti-inflammatory nuclear receptor superfamily in multiple sclerosis patients from Sardinia and Sweden

Neurobiology of Disease, 2005
Several nuclear hormone receptors have been associated with inflammatory reactions. Particularly, liver X receptors (LXRs) have recently been identified as key transcriptional regulators of genes involved in lipid homeostasis and inflammation.
Xuan Liu, Knut R. Steffensen, Alessandra Sanna, Giannina Arru, Maria Laura Fois, Giulio Rosati, Stefano Sotgiu, Hans Link, Jan-Åke Gustafsson, Yu-Min Huang   +9 more
doaj   +1 more source

Benign Prostate Hyperplasia Meets Liver X Receptor [PDF]

Endocrinology, 2012
Viennois and co-workers (1) characterized Lxr knockout mice that, interestingly, develop hyperplasia of the ventral prostate. The Lxr-knockout mice have the potential to develop into a novel and very important mouse model system for benign prostate hyperplasia (BPH) with similar symptoms as in human such as hyperproliferative epithelium and ...
openaire   +2 more sources

Clustering nuclear receptors in liver regeneration identifies candidate modulators of hepatocyte proliferation and hepatocarcinoma.

PLoS ONE, 2014
Background & aimsLiver regeneration (LR) is a valuable model for studying mechanisms modulating hepatocyte proliferation. Nuclear receptors (NRs) are key players in the control of cellular functions, being ideal modulators of hepatic proliferation and ...
Michele Vacca, Simona D'Amore, Giusi Graziano, Andria D'Orazio, Marica Cariello, Vittoria Massafra, Lorena Salvatore, Nicola Martelli, Stefania Murzilli, Giuseppe Lo Sasso, Renato Mariani-Costantini, Antonio Moschetta   +11 more
doaj   +1 more source

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy [PDF]

, 1992
The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and ...
Eisenmenger, Wolfgang, Funk, B., Hansmann, A., Kessler, U., Kiess, W., Kolb, H. J.   +5 more
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Nuclear receptors and clearance of apoptotic cells: stimulating the macrophage’s appetite

Frontiers in Immunology, 2014
Clearance of apoptotic cells by macrophages occurs as a coordinated process to ensure tissue homeostasis. Macrophages play a dual role in this process; first, a rapid and efficient phagocytosis of the dying cells is needed to eliminate uncleared corpses ...
Noelia eAlonso-Gonzalez, Andrés eHidalgo   +1 more
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