Results 111 to 120 of about 449,258 (311)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Gender Bias and Organ Transplantation in Nepal [PDF]

, 2016
Women in Nepal are less likely to receive proper, high quality medical care than their male relatives. Live-donor kidney transplantation provides a compelling example of such disparities, as 84% of recipients are male, 75% of donors are female and most ...
Paneru, Pragya, Rasmussen, Sarah, Shrestha, Kalpana, Shrestha, Pukar C.   +3 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin–Mediated MitophagySummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Hepatic ischemia-reperfusion injury is a significant complication of partial hepatic resection and liver transplantation, impacting the prognosis of patients undergoing liver surgery.
Yu Zhang, Ziyi Wang, Chenyang Jia, Wenjie Yu, Xiangdong Li, Nan Xia, Huiling Nie, Likalamu Pascalia Wikana, Minhao Chen, Yong Ni, Sheng Han, Liyong Pu   +11 more
doaj   +1 more source

Organ Quality as a Complicating Factor in Proposed Systems of Inducements for Organ Donation [PDF]

, 2014
En typisk funktion på startsidan till många webbportaler är den webbdel som presenterar exempelvis desenaste blogginläggen, nyheterna eller händelserna som har lagts till på webbplatsen. Dessa funktioner ärkända som aggreggeringswebbdelar.
Volk, Michael L.
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Retraction Note: miR-1301 inhibits hepatocellular carcinoma cell migration, invasion, and angiogenesis by decreasing Wnt/β-catenin signaling through targeting BCL9

Cell Death and Disease, 2023
Chao Yang, Yonghua Xu, Feng Cheng, Yuanchang Hu, Shikun Yang, Jianhua Rao, Xuehao Wang   +6 more
doaj   +1 more source

NUF2 regulated the progression of hepatocellular carcinoma through modulating the PI3K/AKT pathway via stabilizing ERBB3

Translational Oncology
Hepatocellular carcinoma (HCC) is among the most prevalent and lethal cancers worldwide. The NDC80 kinetochore complex component NUF2 has been previously identified as up-regulating in HCC and associated with patient prognosis.
Yiwei Liu, Yuming Wang, Jifei Wang, Wangjie Jiang, Yananlan Chen, Jijun Shan, Xiao Li, Xiaofeng Wu   +7 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Nogo-B impairs efferocytosis in monocyte-derived macrophages and exacerbates septic liver injury

JHEP Reports
Background & Aims: Efferocytosis is essential for maintaining tissue homeostasis and resolving inflammation, but this process is compromised during sepsis.
Weizhe Zhong, Jian Xu, Fei Li, Zhu Guan, Haoran Hu, Dongming Wu, Yuechen Wang, Ye Zhang, Yan Bai, Yue Yu, Yun Gao, Ping Wang, Xiongxiong Pan, Zhuqing Rao, Haoming Zhou, Xuehao Wang   +15 more
doaj   +1 more source