Results 81 to 90 of about 449,258 (311)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

MicroRNA-98 Inhibits Hepatic Stellate Cell Activation and Attenuates Liver Fibrosis by Regulating HLF Expression

Frontiers in Cell and Developmental Biology, 2020
Liver fibrosis is a major endpoint of patients with chronic liver diseases. The molecular mechanisms behind liver fibrosis remain largely unknown. Many studies have indicated the role of microRNA (miRNA) in hepatic tumorigenesis. But the role of miRNA in
Qi Wang, Qi Wang, Qi Wang, Qi Wang, Qi Wang, Song Wei, Song Wei, Song Wei, Song Wei, Song Wei, Haoming Zhou, Haoming Zhou, Haoming Zhou, Haoming Zhou, Lei Li, Lei Li, Lei Li, Lei Li, Shun Zhou, Shun Zhou, Shun Zhou, Shun Zhou, Chengyu Shi, Chengyu Shi, Chengyu Shi, Chengyu Shi, Yong Shi, Yong Shi, Yong Shi, Yong Shi, Jiannan Qiu, Jiannan Qiu, Jiannan Qiu, Jiannan Qiu, Ling Lu, Ling Lu, Ling Lu, Ling Lu, Ling Lu, Ling Lu, Ling Lu   +40 more
doaj   +1 more source

Renal homografts in patients with major donor-recipient blood group incompatibilities [PDF]

, 1964
Three documented cases of clinical renal transplantation in which the donor and recipient patients had different major blood types have been presented. The relationship of the donor-recipient pairs ranged from that of sister-to-brother to that of totally
Brittain, RS, Hermann, G, Holmes, JH, Marchioro, TL, Starzl, TE, Stonington, OH, Talmage, DW, Waddell, WR   +7 more
core  

The relevance of EU directive 2010/53/EU for living organ donation practice [PDF]

, 2016
With the recent transposition of Directive 2010/53/EU into the transplant regulation of EU Member States, the time is right to have a closer look at its implications for living organ donation practice.
Burnapp, Lisa, Citterio, Franco, Dor, Frank, Frunza, Mihaela, Johnson, Rachel, Lennerling, Annette, Mamode, Nizam, Sterckx, Sigrid, Van Assche, Kristof, Weimar, Willem, Zuidema, Willij   +10 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Designing knowledge-matching facilities for scaling climate-smart agriculture: A proposal for accelerating food systems’ transformation in a changing climate [PDF]

, 2020
The brief talks about designing knowledge-matching facilities for scaling climate-smart agriculture. This is a priority discussed in the International Workshop on Scaling up and out of Climate-smart Technologies and Practices for Sustainable Agriculture (
Dinesh, Dhanush, Koerner, Jana, Nagano, Akiko   +2 more
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source