Results 171 to 180 of about 53,126,315 (234)

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

LL-37 selectively targets Plasmodium-infected erythrocytes and exhibits antimalarial activity. [PDF]

PLoS Pathog
He X, Zhang Y, Lou J, Wu J, Xu S, Zhu G, Tang J, Fang Y, Cao J.   +8 more
europepmc   +1 more source

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Human cathelicidin peptide LL-37 compacts nucleic acids and alters neutrophil extracellular trap structure. [PDF]

Sci Rep
Zielke C, Rad B, Nielsen JE, Li J, Pimcharoen S, Sawant M, Kamayirese S, Lin JS, Thiam HR, Barron AE.   +9 more
europepmc   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Ion‐Exchange‐Driven Ternary Organic Neuromorphic Devices with High Efficiency and Stability

Advanced Science, EarlyView.
Spontaneous ion exchange in a ternary polymer–ionic liquid blend disrupts the phase‐separated ionic domains of the binary film and creates a more homogeneous polymer–ion environment. This ionically reorganized matrix enables stable and efficient electrochemical doping, leading to ion‐gel‐gated organic electrochemical transistors with enhanced ...
Sungmin Lee, Vivek Pratap Singh, Hyeonryul Lee, Young‐Yong Kim, Yong‐Ryun Jo, Changhoon Lee, Ji Hoon Shim, Namsoo Lim, Guanjie Wang, Junyeong Sung, Dongyeop Yang, Zhongwu Wang, Liqiang Li, Chandran Balamurugan, Sooncheol Kwon   +14 more
wiley   +1 more source

LL-37 inhibits osteosarcoma progression by suppressing SQLE-mediated cholesterol synthesis via the PTEN/AKT/mTOR pathway. [PDF]

J Bone Oncol
Lu F, Liu Z, Jiang H, Zheng H, Su W, Zhou B.   +5 more
europepmc   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Dermofunctional Vehicle Downregulates LL-37 and MMPs and Upregulates IGFBP-3. [PDF]

Curr Issues Mol Biol
Polonini H, da Silva Olímpio FR, Oliveira CR.   +2 more
europepmc   +1 more source