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LL-37: An Immunomodulatory Antimicrobial Host Defence Peptide
2012Cationic host defence peptides (CHDP) are conserved peptide components of the innate immune system. These peptides, also known as antimicrobial peptides, were originally discovered and described on the basis of their direct microbicidal properties. However, it has become increasingly clear that CHDP, such as the human cathelicidin hCAP18/LL-37, have an
Paula E. Beaumont +2 more
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Humoral response against LL-37 in psoriatic disease
2019Psoriatic disease is a chronic inflammatory syndrome characterized by skin, joint, and spine involvement leading to abnormal keratinocyte proliferation and/or arthritis with enthesitis (1, 2). The immune response against self-DNA is thought to be central in psoriasis (PsO) pathogenesis (3, 4), while less clear are the mechanisms of the eventual ...
De Santis, Maria +9 more
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Biophysical characterisation of LL-37-derived antimicrobial peptides
2016Antimicrobial peptides (AMPs) are a novel class of therapeutics with activity against bacteria. Such peptides mostly act by disrupting bacterial cytoplasmic membrane. Therefore, membrane composition as well as peptide properties are both important in determining a peptide’s level of activity. Such peptides may have both positive and negative additional
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Het antimicrobiële peptide LL-37: Vriend of vijand?
Nederlands Tijdschrift voor Dermatologie en Venereologie, 2011Baerveldt, Ewout, Thio, Bing
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