Results 261 to 270 of about 1,333,743 (274)

Antibiofilm properties of cathelicidin LL-37: an in-depth review

World Journal of Microbiology and Biotechnology, 2023
Notwithstanding ceaseless endeavors toward developing effective antibiofilm chemotherapeutics, biofilm-associated infections continue to be one of the most perplexing challenges confronting medicine today. Endogenous host defense peptides, such as the human cathelicidin LL-37, are being propounded as promising options for treating such infectious ...
Hamed Memariani, Mojtaba Memariani
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Inactivation of the antimicrobial peptide LL-37 by pathogenic Leptospira

Microbial Pathogenesis, 2021
Leptospires are aerobic, Gram-negative spirochetes with a high invasive capacity. Pathogenic leptospires secrete proteases that inactivate a variety of host's proteins including molecules of the extracellular matrix and of the human complement system. This strategy, used by several pathogens of medical importance, contributes to bacterial invasion and ...
Priscila N. Oliveira, Daniella S. Courrol, Rosa Maria Chura-Chambi, Ligia Morganti, Gisele O. Souza, Marcia R. Franzolin, Elsio A. Wunder, Marcos B. Heinemann, Angela S. Barbosa   +8 more
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The role of the multifunctional peptide LL-37 in host defense

Frontiers in Bioscience, 2008
Neutrophil granules contain several antimicrobial peptides (AMPs) that are important effector molecules of innate immunity. In mammals, the main families of these peptides are the cathelicidins and defensins. Several defensins have been characterized in humans, while there is only one human cathelicidin, designated LL-37.
Ylva, Kai-Larsen, Birgitta, Agerberth
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Circulating LL‐37 is a biomarker for eczema severity in children

Journal of the European Academy of Dermatology and Venereology, 2011
AbstractBackground  Eczema lesions are characterized by impaired expression of antimicrobial peptides such as cathelicidin, which play crucial roles in the innate immune defence against cutaneous infections. LL‐37 corresponds to amino acids 134–170 of human cathelicidin and is a multifunctional host defence molecule essential for normal immune ...
T F, Leung, K W, Ching, A P S, Kong, G W K, Wong, J C N, Chan, K L, Hon   +5 more
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Salivary concentration of the antimicrobial peptide LL-37 in children

Archives of Oral Biology, 2012
Antimicrobial peptides are important components of innate immunity, especially in the unique environment of the oral cavity. Lack of the human cathelicidin LL-37 has been implicated in severe periodontitis, whilst high salivary levels of LL-37 seem to increase caries resistance.
Sotiria, Davidopoulou, Eudoxia, Diza, Georgios, Menexes, Sotirios, Kalfas   +3 more
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Low serum levels of cathelicidin LL-37 in leprosy

Acta Tropica, 2011
The antimicrobial peptide cathelicidin LL-37 possesses antituberculous activity, its association with other mycobacterial diseases, such as leprosy, is unknown. We studied serum cathelicidin and 25OH-vitamin D3 levels in 29 leprosy patients and 19 healthy individuals from Yemen.
Michael, Matzner, Abdul Rahim, Al Samie, Heide-Maria, Winkler, Johannes, Nemeth, Andreas, Grasnek, Alexander, Indra, Christian, Bieglmayer, Stefan, Winkler   +7 more
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Preparation of LL-37-Grafted Titanium Surfaces with Bactericidal Activity

Bioconjugate Chemistry, 2006
Modification of material surfaces aimed at bestowing them with antimicrobial properties is a promising approach in the development of new biomaterials. Antimicrobial peptides (AMPs) are an attractive alternative to conventional antibiotics because of lack of toxicity, inherently high selectivity, and absence of immune response.
Gabriel, M.O., Nazmi, K., Veerman, E.C.I., van Nieuw Amerongen, A., Zentner, A.   +4 more
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Assays for Identifying Inducers of the Antimicrobial Peptide LL-37

2016
One promising approach to meet the growing problem of antibiotic resistance is to modulate host defense mechanisms, i.e., host-directed therapy (HDT), in the fight against infections. Induction of endogenous antimicrobial peptides (AMPs) via small molecular compounds, such as 1,25-dihydroxyvitamin D3 or phenylbutyrate, could provide one such HDT-based ...
Frank, Nylén, Peter, Bergman, Gudmundur H, Gudmundsson, Birgitta, Agerberth   +3 more
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Human Cathelicidin LL-37 Prevents Bacterial Biofilm Formation

Future Medicinal Chemistry, 2012
Human pathogens often colonize their host by the formation of biofilms. These surface-attached aggregates of bacteria are characterized by a self-produced extracellular matrix, which makes them highly resistant towards antibiotic treatment. Their abilities to adhere to abiotic surfaces (e.g., catheters and other medical devices) also makes bacterial ...
Skovgård Jacobsen , Andreas, Jenssen, Håvard; id_orcid 0000-0003-0007-0335   +1 more
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ChemInform Abstract: The Chemistry and Biology of LL‐37

ChemInform, 2010
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Matthew F. Burton, Patrick G. Steel
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