Results 261 to 270 of about 56,247,789 (275)
Some of the next articles are maybe not open access.
LL-37 expression in the skin in systemic lupus erythematosus
Lupus, 2011The objective of this study was to investigate the expression and relationship of LL-37, plasmacytoid dendritic cells (pDCs) and interferon-alpha (IFN-α) in skin in systemic lupus erythematosus (SLE), and their role in SLE pathogenesis. Skin biopsies were taken from nine SLE patients and six healthy volunteers.
C-L, Sun, F-Z, Zhang, P, Li, L-Q, Bi
openaire +2 more sources
The role of the multifunctional peptide LL-37 in host defense
Frontiers in Bioscience, 2008Neutrophil granules contain several antimicrobial peptides (AMPs) that are important effector molecules of innate immunity. In mammals, the main families of these peptides are the cathelicidins and defensins. Several defensins have been characterized in humans, while there is only one human cathelicidin, designated LL-37.
Ylva, Kai-Larsen, Birgitta, Agerberth
openaire +2 more sources
Low serum levels of cathelicidin LL-37 in leprosy
Acta Tropica, 2011The antimicrobial peptide cathelicidin LL-37 possesses antituberculous activity, its association with other mycobacterial diseases, such as leprosy, is unknown. We studied serum cathelicidin and 25OH-vitamin D3 levels in 29 leprosy patients and 19 healthy individuals from Yemen.
Michael, Matzner +7 more
openaire +2 more sources
Cubosomes for topical delivery of the antimicrobial peptide LL-37
European Journal of Pharmaceutics and Biopharmaceutics, 2019In this study, the use of cubosomes for topical delivery of the antimicrobial peptide (AMP) LL-37 was investigated. Topical delivery of AMPs is of great interest for treatment of skin infections caused by bacteria, such as Staphylococcus aureus. AMP containing cubosomes were produced by three different preparation protocols and compared: (i) pre ...
Lukas Boge +9 more
openaire +2 more sources
Preparation of LL-37-Grafted Titanium Surfaces with Bactericidal Activity
Bioconjugate Chemistry, 2006Modification of material surfaces aimed at bestowing them with antimicrobial properties is a promising approach in the development of new biomaterials. Antimicrobial peptides (AMPs) are an attractive alternative to conventional antibiotics because of lack of toxicity, inherently high selectivity, and absence of immune response.
Gabriel, M.O. +4 more
openaire +4 more sources
Assays for Identifying Inducers of the Antimicrobial Peptide LL-37
2016One promising approach to meet the growing problem of antibiotic resistance is to modulate host defense mechanisms, i.e., host-directed therapy (HDT), in the fight against infections. Induction of endogenous antimicrobial peptides (AMPs) via small molecular compounds, such as 1,25-dihydroxyvitamin D3 or phenylbutyrate, could provide one such HDT-based ...
Frank, Nylén +3 more
openaire +2 more sources
Human Cathelicidin LL-37 Prevents Bacterial Biofilm Formation
Future Medicinal Chemistry, 2012Human pathogens often colonize their host by the formation of biofilms. These surface-attached aggregates of bacteria are characterized by a self-produced extracellular matrix, which makes them highly resistant towards antibiotic treatment. Their abilities to adhere to abiotic surfaces (e.g., catheters and other medical devices) also makes bacterial ...
Skovgård Jacobsen , Andreas +1 more
openaire +3 more sources