Results 131 to 140 of about 15,588 (275)

Emerging roles of liquid-liquid phase separation in liver innate immunity

Cell Communication and Signaling
Biomolecular condensates formed by liquid-liquid phase separation (LLPS) have become an extensive mechanism of macromolecular metabolism and biochemical reactions in cells.
Xinying Zhang, Ziyue Yang, Chunmeng Fu, Run Yao, Huan Li, Fang Peng, Ning Li   +6 more
doaj   +1 more source

Uncovering a previously unknown function of polyphosphate in polyadenylated RNA‐induced amyloidogenesis of Hfq

The FEBS Journal, EarlyView.
Polyphosphate interaction with Hfq and RNA drives phase separation and amyloid self‐assembly, uncovering a previously unrecognized role for polyP in bacterial stress responses. Our findings reveal new insights into the molecular mechanisms of RNA‐mediated phase separation, highlighting the role of polyP as a key modulator of this process. Polyphosphate
Kevin Mosca, Florian Turbant, Sambhasan Banerjee, Frank Wien, Richard R. Sinden, Véronique Arluison   +5 more
wiley   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

Stress testing credit risk: a survey of authorities' approaches [PDF]

This paper reviews the quantitative methods used at selected central banks to stress testing credit risk, focusing in particular on the methods used to link macroeconomic drivers of stress with bank specific measures of credit risk (macro stress test ...
Antonella Foglia
core  

Do Fair Value Adjustments Excluded From Net Income Convey New Information That Is Complementary to GAAP Earnings?

Journal of Business Finance &Accounting, EarlyView.
ABSTRACT We use banks’ quarterly fair value disclosures to perform the first short‐window event study of fair value adjustments excluded from net income and offer three main results. First, we find that fair value adjustments for banks’ loan portfolios are positively associated with short‐window stock returns and that they impact investors’ response to
John L. Campbell, Samuel O. Davidson, Catherine Shakespeare   +2 more
wiley   +1 more source

Smartphone language and resting‐state EEG indicators of self‐focused attention prospectively predict major depressive disorder risk in adolescents

Journal of Child Psychology and Psychiatry, EarlyView.
Background Central to major depressive disorder (MDD) onset and maintenance is maladaptive self‐focused attention, which can be reliably indexed by greater: (a) usage of first‐person singular pronouns (e.g., I) in natural language and (b) alpha oscillations in resting‐state EEG.
Lilian Y. Li, Nayoung Kim, Esha Trivedi, Sarah E. Sarkas, Madeline M. McGregor, Aishwarya Sritharan, Katherine Durham, Ivan Alekseichuk, Allison M. Letkiewicz, Vijay A. Mittal, David Pagliaccio, Nicholas B. Allen, Randy P. Auerbach, Stewart A. Shankman   +13 more
wiley   +1 more source

Transcriptional adapter ADA2 regulates yield and end‐use quality through liquid–liquid phase separation in wheat

Journal of Integrative Plant Biology, EarlyView.
The transcriptional adapter ADA2 interacts with the histone acetyltransferase GCN5 to regulate starch and storage protein content in wheat grains through histone acetylation. ADA2 undergoes phase separation and is modulated by GCN5, affecting histone acetyltransferase activity and gene transcription.
Xiaobang Zhang, Ruijie Zhang, Yuhan Zhang, Tao Yang, Longfei Wu, Yuan Cao, Jun Xiao, Jigang Li, Xin Gao, Xinyou Cao, Jie Liu, Mingming Xin, Yuan Zong, Zhongfu Ni, Qixin Sun, Yingyin Yao   +15 more
wiley   +1 more source

Technical Proposal for FASER: ForwArd Search ExpeRiment at the LHC

, 2018
FASER is a proposed small and inexpensive experiment designed to search for light, weakly-interacting particles during Run 3 of the LHC from 2021-23. Such particles may be produced in large numbers along the beam collision axis, travel for hundreds of ...
Ariga, Akitaka, Ariga, Tomoko, Boyd, Jamie, Cadoux, Franck, Casper, David W., Cerutti, Francesco, Danzeca, Salvatore, Dougherty, Liam, FASER Collaboration, Favre, Yannick, Feng, Jonathan L., Ferrere, Didier, Gall, Jonathan, Galon, Iftah, Gonzalez-Sevilla, Sergio, Hsu, Shih-Chieh, Iacobucci, Giuseppe, Kajomovitz, Enrique, Kling, Felix, Kuehn, Susanne, Lamont, Mike, Levinson, Lorne, Osborne, John, Otono, Hidetoshi, Petersen, Brian, Sabate-Gilarte, Marta, Sato, Osamu, Schott, Matthias, Sfyrla, Anna, Smolinsky, Jordan, Soffa, Aaron M., Takubo, Yosuke, Thonet, Pierre, Torrence, Eric, Trojanowski, Sebastian, Zhang, Gang   +35 more
core  

The Effects of Regulatory Office Closures on Bank Behavior

Journal of Money, Credit and Banking, EarlyView.
Abstract We investigate if the decentralized structure of regulatory office networks influences supervisory outcomes and bank behavior. Following the closure of an office, banks previously supervised by that office increase their lending and risk‐taking.
IVAN LIM, JENS HAGENDORFF, SETH ARMITAGE
wiley   +1 more source