Dysregulation of liquid-liquid phase separation: from molecular mechanisms to targeted therapies in cardiovascular diseases. [PDF]
J NanobiotechnologyZhang X +5 more
europepmc +1 more source
Attention Based Optimization for 3D Shape Registration
Computer Graphics Forum, EarlyView.Abstract Transformers are sequence‐to‐sequence architectures originally designed to handle structurally rigid and order‐sensitive data, such as text and images. At their core, they exploit the attention mechanism, which is permutation‐equivariant and relies on computing token‐to‐token relationships.
A. Riva, L. Olearo, S. Melzi
wiley +1 more source
Liquid-liquid phase separation-associated gene networks link EMT and ferroptosis to define a PDGFRB-centered prognostic signature in bladder cancer. [PDF]
Front ImmunolZhang X, Ge P, Chen Q, Wang S, Yang D.
europepmc +1 more source
Advances in 4D Representation: Geometry, Motion, and Interaction
Computer Graphics Forum, EarlyView.We survey 4D representation through three key pillars — geometry, motion, and interaction — offering a selective, representation‐centric perspective to guide researchers in choosing and customizing the right 4D representation for their tasks. Abstract We present a survey on 4D generation and reconstruction, a fast‐evolving subfield of computer graphics
M. Zhao +7 more
wiley +1 more source
A Systematic Evaluation of Protein Phase Separation Predictors across Diverse Protein Landscapes. [PDF]
Comput Struct Biotechnol JGilroy KE, Barr JN.
europepmc +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Sodium‐glucose co‐transporter 2 inhibitors (SGLT2i) improve cardiovascular and renal outcomes in type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD) and chronic heart failure (CHF). Despite clinical guideline recommendations, SGLT2i uptake in UK primary care remains suboptimal and information on utilisation is limited.
Chelsea Stefanska +6 more
wiley +1 more source
Exclusion of RNA-binding domains from G-quadruplex condensates by G-quadruplex ligands. [PDF]
RSC Chem BiolHashimoto Y +8 more
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Deregulation, government failure, and tragedy: The Report of Phase 2 of the Grenfell Tower Inquiry
Economic Affairs, EarlyView.Abstract The Inquiry into the fire at Grenfell Tower, London, in 2017 has exposed the failures that led to the tragedy in a commendably exhaustive manner. But the explanation of those failures is seriously inadequate. First, they are attributed to deregulation, when the Inquiry itself details the ways in which the cladding of the building was subject ...
David Campbell
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amyloid-predict and LLPS-predict: Predicting phase separation propensities in the intrinsically disordered proteome. [PDF]
Proc Natl Acad Sci U S ALobo S, Griem L, Shell MS, Shea JE.
europepmc +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source