Results 71 to 80 of about 7,849 (242)

When Is a Partner/LLP Member Not a Partner/LLP Member? The Interface with Employment and Worker Status [PDF]

Industrial Law Journal, 2017
Abstract The answer to the question of whether a partner can also simultaneously be an employee of his partnership has long been considered to be settled law. However, the introduction of limited liability partnerships (LLPs) in 2001 has not only raised the new question of whether LLP members can also be employees but has, in doing so ...
openaire   +1 more source

Phase separation and the tumor microenvironment

Cell Communication and Signaling
Liquid-Liquid Phase Separation (LLPS) is a physicochemical process which involves biomolecules spontaneously assembling into membrane-less biomolecular condensates through multivalent weak interactions.
Wangwang Liu, Linhong Yu, Jianguo Xu, Yihan Yao, Tuomas P. J. Knowles, Yan-Li Zhang   +5 more
doaj   +1 more source

Bacteria‐Derived 1‐Allylpiperazine Alleviates Symptoms of Parkinson's Disease Model by Promoting Autophagy

Advanced Science, EarlyView.
Parkinson's disease currently has no disease‐modifying therapies. In Caenorhabditis elegans, Escherichia coli E8 alleviates α‐synuclein‐provoked PD‐related defects through its bioactive metabolite 1‐ALPP, which combats PD by triggering AMPK/mTOR/HLH‐30‐dependent autophagy and suppressing α‐synuclein LLPS‐mediated fibrillization.
Mingqin Qu, Xinyuan Zhang, Xinyi Chen, Jiaxin Shi, Meng Xu, Fuhao Wang, Jinling Lv, Jiaman Sun, Weiyi Niu, Zihan Liu, Li Li, Fufeng Liu, Xiangming Wang   +12 more
wiley   +1 more source

Phase separation of a PKA type I regulatory subunit regulates β-cell function through cAMP compartmentalization.

PLoS Biology
Cyclic adenosine monophosphate (cAMP), a ubiquitous second messenger, regulates a variety of cellular functions with high specificity. We previously showed that the type I regulatory subunit of cAMP-dependent protein kinase A (PKA), RIα, undergoes liquid-
Ha Neul Lee, Julia C Hardy, Emily H Pool, Jin-Fan Zhang, Su Hyun Kim, William F Buhl, Jessica G H Bruystens, Sohum Mehta, Susan S Taylor, Jin Zhang   +9 more
doaj   +1 more source

The role of the MYL12A liquid-liquid phase separation in neutrophil improves the prognosis of acute respiratory distress syndrome: a multi-omics analysis

Frontiers in Immunology
BackgroundIn acute respiratory distress syndrome (ARDS), neutrophils, as the primary effector immune cells, undergo profound transcriptional and phenotypic reprogramming in response to complex inflammatory stimuli, modulating signal transduction and ...
Yufang Guo, Yufang Guo, Longjie Li, Longjie Li, Yongjun Wang, Zexu Wang, Wei Qiu, Qian Li, Li Wang, Bing Wan   +9 more
doaj   +1 more source

A Protocol for Regulating Protein Liquid–Liquid Phase Separation Using NMR-Guided Mutagenesis

Methods and Protocols
Liquid–liquid phase separation (LLPS) underlies the formation of membraneless cellular compartments, yet experimental strategies that directly connect quantitative LLPS behavior with residue-level structural information remain limited.
Mayu Enomoto-Kusano, Kyoko Furuita, Takashi S. Kodama, Chojiro Kojima   +3 more
doaj   +1 more source

Role of liquid–liquid phase separation in cancer: Mechanisms and therapeutic implications

Cancer Innovation
Liquid–liquid phase separation (LLPS) has emerged as a pivotal biological phenomenon involved in various cellular processes, including the formation of membrane‐less organelles and the regulation of biomolecular condensates through precise spatiotemporal
Xuesong Li, Zhuo Yu
doaj   +1 more source

Multi-omics analysis identifies a liquid-liquid phase separation-related subtypes in head and neck squamous cell carcinoma

Frontiers in Oncology
BackgroundGrowing evidence indicates that abnormal liquid–liquid phase separation (LLPS) can disrupt biomolecular condensates, contributing to cancer development and progression.
Peng-Lei Zhai, Peng-Lei Zhai, Meng-Min Chen, Meng-Min Chen, Meng-Min Chen, Qi Wang, Jing-Jun Zhao, Xiao-Mei Tang, Cui-Ni Lu, Jia Liu, Qin-Xin Yang, Ming-Liang Xiang, Qing-Hai Tang, Biao Gu, Shu-Ping Zhang, Si-Ping Tang, Da Fu, Da Fu   +17 more
doaj   +1 more source

Bioinformatic approaches of liquid–liquid phase separation in human disease

Chinese Medical Journal
. Biomolecular aggregation within cellular environments via liquid–liquid phase separation (LLPS) spontaneously forms droplet-like structures, which play pivotal roles in diverse biological processes.
Jun Sun, Yilong Chen, Ruiye Bi, Yong Yuan, Haopeng Yu, Yuanyuan Ji   +5 more
doaj   +1 more source

Integration of single-cell and bulk RNA sequencing data to identify liquid–liquid phase separation-related prognostic biomarkers in hepatocellular carcinoma

Scientific Reports
Liquid–liquid phase separation (LLPS) has been linked to the initiation and progression of cancers. This study aimed to investigate the LLPS-related molecular features and develop a prognostic signature for hepatocellular carcinoma (HCC). Single-cell RNA
Yanjun Luo, Xiaoming Wang
doaj   +1 more source