Results 71 to 80 of about 10,769 (286)

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology
Liquid–liquid phase separation (LLPS) plays a critical role in orchestrating various cellular processes, such as gene expression, signal transduction, and protein synthesis, by compartmentalizing cellular components without membrane boundaries.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
doaj   +1 more source

A novel liquid-liquid phase separation-related gene signature for predicting prognosis in colon cancer

Frontiers in Immunology
BackgroundAn increasing body of evidence indicates that dysregulation of liquid-liquid phase separation (LLPS) in cellular processes is implicated in the development of diverse tumors. Nevertheless, the association between LLPS and the prognosis, as well
Shuo Wang, Shuo Wang, Sen Hou, Sen Hou, Shan Jiang, Chao Wang, Chao Wang, Peipei Zhang, Yingjiang Ye, Yingjiang Ye, Zhidong Gao, Zhidong Gao   +11 more
doaj   +1 more source

LLPS of FUS as modulated by ATP and nucleic acids.

, 2019
(A) FUS and its domains used in the present study for characterizing the modulation of their LLPS by ATP, AMP, and adenosine, as well as one RNA and two ssDNA molecules (B).
Liangzhong Lim (229433), Yimei Lu (319556), Jian Kang (118630), Jianxing Song (143189)   +3 more
core   +1 more source

Chromatin Liquid–Liquid Phase Separation (LLPS) Is Regulated by Ionic Conditions and Fiber Length

, 2022
The dynamic regulation of the physical states of chromatin in the cell nucleus is crucial for maintaining cellular homeostasis. Chromatin can exist in solid- or liquid-like forms depending on the surrounding ions, binding proteins, post-translational ...
Qinming Chen, Hao Li, Nordenskiöld, Lars, Jindi Li, Arkhipova, Anastasia Yu, Lei Zhao, Chen, Qinming, Li, Hao, Chen, Yinglu, Aghil Soman, Zhao, Lei, Yinglu Chen, Xiangyan Shi, Soman, Aghil, Anastasia Yu Arkhipova, Li, Jindi, Shi, Xiangyan, Lars Nordenskiöld   +17 more
core   +1 more source

A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers

Advanced Science, EarlyView.
Phase separation and aging of intrinsically disordered proteins are placed in a unifying framework. A thermodynamically consistent time‐dependent version of associating‐polymer theory shows how the processes are intricately coupled. Assuming aging to occur through interacting sites resulting from reversible conformational transitions, the model ...
Jasper J. Michels, Joana Caria, Edward A. Lemke   +2 more
wiley   +1 more source

Targeting LLPS in disease: a new modality in drug development [PDF]

, 2023
Biomolecular condensation is a process whereby many macromolecules (proteins and RNAs) form non-stoichiometric, functional assemblies. The dominant mechanism of such biomolecular condensation is liquid-liquid phase separation (LLPS), which leads to the
Tompa, Peter
core  

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Molecular mechanisms mediated by liquid-liquid phase separation in chronic liver disease progression

iScience
Summary: Liquid-liquid phase separation (LLPS) is a cellular process driven by multivalent interactions, forming dynamic biomolecular condensates containing proteins, RNAs, and other molecules.
Xinran Qiu, Haoyuan Tian, Yuanyuan Gao, Junrui Wang, Zhengyang Bao, Ningyu Qiu, Feng Zhang, Zili Zhang, Feixia Wang, Shizhong Zheng, Jiangjuan Shao   +10 more
doaj   +1 more source

Multivalent interactions mediated in vitro LLPS

, 2020
Multivalent interactions are a major driving force behind protein liquid-liquid phase separation. Proteins capable of undergoing LLPS owe their multivalency to the presence of intrinsically disordered regions (IDRs).
Wang, Fengyi
core