Results 71 to 80 of about 15,588 (275)

Molecular mechanisms mediated by liquid-liquid phase separation in chronic liver disease progression

iScience
Summary: Liquid-liquid phase separation (LLPS) is a cellular process driven by multivalent interactions, forming dynamic biomolecular condensates containing proteins, RNAs, and other molecules.
Xinran Qiu, Haoyuan Tian, Yuanyuan Gao, Junrui Wang, Zhengyang Bao, Ningyu Qiu, Feng Zhang, Zili Zhang, Feixia Wang, Shizhong Zheng, Jiangjuan Shao   +10 more
doaj   +1 more source

Influence of particle-phase state on the hygroscopic behavior of mixed organic-inorganic aerosols [PDF]

, 2015
Recent work has demonstrated that organic and mixed organic–inorganic particles can exhibit multiple phase states depending on their chemical composition and on ambient conditions such as relative humidity (RH).
Flagan, R. C., Hodas, N., Mui, W., Seinfeld, J. H., Zuend, A.   +4 more
core   +3 more sources

Time‐Resolved Native Mass Spectrometry Reveals Reversible Light‐Driven Oligomerization of Arabidopsis Cryptochrome 1 and Its Antagonism by BIC1

Angewandte Chemie International Edition, EarlyView.
Time‐resolved native mass spectrometry uncovers the blue‐light‐dependent kinetic mechanism of Arabidopsis CRY1 oligomerization, proceeding sequentially from monomers to dimers and tetramers. ATP promotes assembly, whereas BIC1 actively blocks and disassembles tetramers independent of light, providing mechanistic insight into the regulation of ...
Alicia Just, Nils Niemann, Petra Gnau, Dennis Kock, Thomas Heimerl, Stephan Kiontke, Lars‐Oliver Essen, Alfred Batschauer, Nina Morgner   +8 more
wiley   +1 more source

Monetary and Macroprudential Policy and Welfare in an Estimated Four‐Agent New Keynesian Model

Journal of Money, Credit and Banking, EarlyView., 2023
Abstract We examine the social and agent‐specific welfare effects of monetary and macroprudential policy in a four‐agent estimated macro‐economic model comprising “banked simple households,” “underbanked simple households,” “firm owners,” and “bank owners.” Optimal capital requirement and loan loss provisions ratios improve all agent‐specific and ...
GEORGE J. BRATSIOTIS, KASUN D. PATHIRAGE
wiley   +1 more source

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics [PDF]

, 2017
Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA metabolism, including stress granules.
Abigail M. Janke, Aguzzi, Albert Konijnenberg, Alex Volkov, Altmeyer, Andersen, Ash, Aumiller, Boeynaems, Boeynaems, Brangwynne, Brangwynne, Brangwynne, Burke, Castello, Ciryam, Conicella, Cox, Cox, David, DeJesus-Hernandez, Denes Kovacs, Dirk Daelemans, Dormann, Edbauer, Elke Bogaert, Emara, Evy Timmerman, Figley, Francis Impens, Frank Sobott, Frederic Rousseau, Freibaum, Frey, Hawe, Hennig, J. Paul Taylor, Jain, Joost Schymkowitz, Jovičić, Kato, Kedersha, Kedersha, Kedersha, Kim, King, Kwon, Lee, Lin, Lin, Liu, Lopez-Gonzalez, Ludo Van Den Bosch, Mainak Guharoy, March, Mathias De Decker, Mitrea, Mizielinska, Molliex, Mori, Murakami, Nancy Kedersha, Nicolas L. Fawzi, Nott, Olzscha, Patel, Paul Anderson, Peter Tompa, Philip Van Damme, Pieter Baatsen, Ramaswami, Regina-Maria Kolaitis, Renton, Renton, Schwartz, Steven Boeynaems, Tao, Thandapani, Thomas Vercruysse, Tiraferri, Tom Jaspers, Tompa, Tompa, Topisirovic, Varadi, Veronica H. Ryan, Wen, Wheeler, Wim Robberecht, Yamakawa, Zhang   +90 more
core   +4 more sources

Long-lived proteins and DNA as candidate predictive biomarkers for tissue associated diseases

iScience
Summary: Protein turnover is an important mechanism to maintain proteostasis. Long-lived proteins (LLPs) are vulnerable to lose their function due to time-accumulated damages.
Xiaosong Liu, Bozidar Novak, Christian Namendorf, Barbara Steigenberger, Yaoyang Zhang, Christoph W. Turck   +5 more
doaj   +1 more source

Inelastic Dark Matter at the LHC Lifetime Frontier: ATLAS, CMS, LHCb, CODEX-b, FASER, and MATHUSLA

, 2018
Visible signals from the decays of light long-lived hidden sector particles have been extensively searched for at beam dump, fixed-target, and collider experiments.
Berlin, Asher, Kling, Felix
core   +1 more source

Construction of a CO2‐Fixing Compartment Using a Shape‐Transforming DNA Scaffold

Chemistry – A European Journal, EarlyView.
A shape‐transforming DNA scaffold encapsulates RuBisCO within a controllable, self‐contacting compartment that mimics the carboxysome. The scaffold switches between open and closed states, enabling direct comparison of identical enzyme populations in different microenvironments.
Hui Yang, Peng Lin, Surachada Chuaychob, Huyen Dinh, Mei Nakabayashi, Eiji Nakata, Takashi Morii   +6 more
wiley   +1 more source

Phase separation of a PKA type I regulatory subunit regulates β-cell function through cAMP compartmentalization.

PLoS Biology
Cyclic adenosine monophosphate (cAMP), a ubiquitous second messenger, regulates a variety of cellular functions with high specificity. We previously showed that the type I regulatory subunit of cAMP-dependent protein kinase A (PKA), RIα, undergoes liquid-
Ha Neul Lee, Julia C Hardy, Emily H Pool, Jin-Fan Zhang, Su Hyun Kim, William F Buhl, Jessica G H Bruystens, Sohum Mehta, Susan S Taylor, Jin Zhang   +9 more
doaj   +1 more source

Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation. [PDF]

, 2019
RNA Polymerase II (Pol II) and transcription factors form concentrated hubs in cells via multivalent protein-protein interactions, often mediated by proteins with intrinsically disordered regions.
Darzacq, Xavier, Dugast-Darzacq, Claire, Hansen, Anders S, Hao, Yvonne, Heckert, Alec Basil, Marie-Nelly, Hervé, McSwiggen, David Trombley, Teves, Sheila S, Tjian, Robert, Umemoto, Kayla K   +9 more
core