Results 91 to 100 of about 7,152 (243)

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, EarlyView.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

Programming Multidomain Peptides With Molecular Frustration Into Biomolecular Condensates

Small, EarlyView.
De novo designed multidomain peptides (MDPs) were used to explore how molecular ordering influences peptide phase behavior. MDPs containing partially folded β‐sheets were found to form biomolecular condensates. This work introduces a new design principle for condensate formation and expand the design space beyond conventional intrinsically disordered ...
Debdatta Das, Jenny N. Nguyen, Navneet Sahoo, Chuanye Xiong, Haritha Asokan‐Sheeja, Yan Chang, Raniyah Ali, Eleanor D. Smith, Chad A. Brautigam, Yi Hong, Zui Pan, Peng Tao, He Dong   +12 more
wiley   +1 more source

Topology‐Encoded Charge Polarity Governs Multiphase Organization in Intrinsically Disordered Protein Polymer Condensates

Small, EarlyView.
Electrostatic topology is shown to program phase separation and internal organization in thermoresponsive intrinsically disordered protein polymer (IDPP) condensates. By comparing oppositely charged IDPPs with a covalent diblock, chain connectivity is revealed to control charge compensation, dense‐phase micropolarity, miscibility, and apparent acid ...
Julio Fernández‐Fernández, Vicente Domínguez‐Arca, Raúl Escribano, Sheila Lorenzo, Sergio Ferrero, Sergio Acosta, José Carlos Rodríguez‐Cabello   +6 more
wiley   +1 more source

Liquid-liquid phase separation in super enhancer-driven oncogenesis: mechanisms, immune evasion, and therapeutic implications

Frontiers in Cell and Developmental Biology
Liquid-Liquid Phase Separation (LLPS) allows biomolecules to form membrane-less organelles or condensates through weak multivalent interactions. Recent studies have revealed the critical role of LLPS in super-enhancer (SE)-associated tumorigenesis ...
Ruoxi Yu, Deyu Sun, Chuang Zhang
doaj   +1 more source

On Causation and Accounts of Profits: Rukhadze v Recovery Partners GP Ltd

The Modern Law Review, EarlyView.
In the recent case of Rukhadze v Recovery Partners GP Ltd, the UK Supreme Court was given the opportunity to reconsider the House of Lords’ previous formulations of the account of profits doctrine in Regal (Hastings) Ltd v Gulliver and Boardman v Phipps.
Fong Jun Yi
wiley   +1 more source

CLAIMING SOCIAL HOUSING FUTURES: Value, Risk and the Temporal Politics of Income Strip Financing in London

International Journal of Urban and Regional Research, EarlyView.
Abstract Asset managers, private equity firms and other institutional investors have assumed an increasingly important role in the ownership and management of housing and infrastructure since the Global Financial Crisis. This article analyses how social housing in London is being transformed into a financial asset through an analysis of ‘income strip ...
Aretousa Bloom, Joe Penny
wiley   +1 more source

Liquid-liquid phase separation in gastric cancer: identifying novel biomarkers and therapeutic targets through gene signature analysis

Frontiers in Immunology
Background and objectiveLiquid-liquid phase separation (LLPS) plays an important role in the development of many tumors, including gastric cancer, but its prognostic value is unclear.
Xianhui Wen, Xianhui Wen, Miaomiao Cui, Junhua Zhang, Hai Huang, Hai Huang   +5 more
doaj   +1 more source

THE VIOLENCE OF FULL COST RECOVERY: Financing Water Infrastructure, and the History and Future of Perpetual Crisis in Mombasa

International Journal of Urban and Regional Research, EarlyView.
Abstract Foregrounding the role of finance, this article examines the historical production and future trajectory of the urban water crisis in Mombasa. Drawing on archival research and contemporary fieldwork, it traces how principles of full cost recovery—institutionalized during the colonial period and later reworked through postcolonial ...
Joe Williams
wiley   +1 more source

catGRANULE 2.0: accurate predictions of liquid-liquid phase separating proteins at single amino acid resolution

Genome Biology
Liquid-liquid phase separation (LLPS) enables the formation of membraneless organelles, essential for cellular organization and implicated in diseases. We introduce catGRANULE 2.0 ROBOT, an algorithm integrating physicochemical properties and AlphaFold ...
Michele Monti, Jonathan Fiorentino, Dimitrios Miltiadis-Vrachnos, Giorgio Bini, Tiziana Cotrufo, Natalia Sanchez de Groot, Alexandros Armaos, Gian Gaetano Tartaglia   +7 more
doaj   +1 more source

IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation

Cell Reports
Summary: Ovarian cancer (OC) is the most lethal gynecological malignancy, and high expression of IGF2BP2 is significantly associated with poor prognosis.
Xueyou Xiong, Xuan Wang, Zhenlong Wang, Feixue Chen, Yaqian Shi, Xiyi Chen, Weijian Gong, Xuemei Jia, Juan Xu   +8 more
doaj   +1 more source