Results 91 to 100 of about 7,849 (242)

MusselFinder: Automated dreissenid mussel density estimation via robotic benthic imaging

Limnology and Oceanography: Methods, EarlyView.
Abstract Despite the widespread need to map the abundance of invasive quagga and zebra mussels (Dreissena spp.) in lakes and reservoirs worldwide, current methods remain limited by data collection and analysis bottlenecks. Autonomous underwater vehicles (AUVs) combined with machine learning (ML) offer a scalable remote sensing approach for estimating ...
Angus Galloway, Peter C. Esselman, Anthony Geglio, Shadi Moradi, Jennifer M. Morris, Joseph Geisz, Magdalena K. Sobol, Graham W. Taylor   +7 more
wiley   +1 more source

Use of the PROMIS and Neuro‐QoL to Evaluate Health‐Related Quality of Life following Unilateral Subthalamic Deep Brain Stimulation for Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Subthalamic nucleus deep brain stimulation (STN DBS) improves Parkinson's disease (PD)‐related motor symptoms, but how STN DBS impacts various aspects of patient‐perceived health‐related quality of life (HRQoL) is less clear. The Patient‐Reported Outcome Measurement Instrument (PROMIS) and Quality of Life in Neurological Disorders ...
Sarah A. Brinkerhoff, Frank Robinson, Roy C. Martin, Sandra Morales, Christopher L. Gonzalez, Christopher P. Hurt, Melissa Wade, Gary Cutter, Gitendra Uswatte, Harrison C. Walker, Victor A. Del Bene   +10 more
wiley   +1 more source

Liquid-liquid phase separation in gastric cancer: identifying novel biomarkers and therapeutic targets through gene signature analysis

Frontiers in Immunology
Background and objectiveLiquid-liquid phase separation (LLPS) plays an important role in the development of many tumors, including gastric cancer, but its prognostic value is unclear.
Xianhui Wen, Xianhui Wen, Miaomiao Cui, Junhua Zhang, Hai Huang, Hai Huang   +5 more
doaj   +1 more source

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting

Medicinal Research Reviews, EarlyView.
ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
wiley   +1 more source

‘We want to be the hosts of this story’: Learning from community‐led approaches to data governance of land use for nature recovery

People and Nature, EarlyView.
Abstract Debates abound regarding how to use land for nature recovery and environmental governance. Such decisions require an understanding of benefits and trade‐offs, and increasingly rely on vast quantities of data, delivered through digital technologies.
Lucy Jenner, Marc J. Metzger, Darren Moseley, Ed Forrest   +3 more
wiley   +1 more source

Crystalline Poly(L‐Lactic Acid) Nanoparticles via Nonsolvent‐Induced Cascade Phase Separation

Journal of Polymer Science, EarlyView.
Water is used as the nonsolvent to induce liquid/liquid phase separation (LLPS) of poly(L‐lactic acid) (PLLA)/propylene carbonate solution and PLLA crystallization. Due to the two levels of cascade LLPS coupled with confined PLLA crystallization, three types of polymeric nanoparticles, including PLLA single crystals, Ouzo crystalsomes, and sheaf‐like ...
Niloofar Esmati, Shichen Yu, Carl T. Furner, Christopher Y. Li   +3 more
wiley   +1 more source

catGRANULE 2.0: accurate predictions of liquid-liquid phase separating proteins at single amino acid resolution

Genome Biology
Liquid-liquid phase separation (LLPS) enables the formation of membraneless organelles, essential for cellular organization and implicated in diseases. We introduce catGRANULE 2.0 ROBOT, an algorithm integrating physicochemical properties and AlphaFold ...
Michele Monti, Jonathan Fiorentino, Dimitrios Miltiadis-Vrachnos, Giorgio Bini, Tiziana Cotrufo, Natalia Sanchez de Groot, Alexandros Armaos, Gian Gaetano Tartaglia   +7 more
doaj   +1 more source

IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation

Cell Reports
Summary: Ovarian cancer (OC) is the most lethal gynecological malignancy, and high expression of IGF2BP2 is significantly associated with poor prognosis.
Xueyou Xiong, Xuan Wang, Zhenlong Wang, Feixue Chen, Yaqian Shi, Xiyi Chen, Weijian Gong, Xuemei Jia, Juan Xu   +8 more
doaj   +1 more source

Self‐Assembly of Hierarchically Structured Materials From Liquid Crystalline Mesophases of Tobacco Mosaic Virus‐Like Particles

Small, EarlyView.
Recombinantly produced Tobacco Mosaic Virus coat protein (TMVcp) helical rods were demonstrated to reproducibly self‐assemble into hierarchically structured macroscopic filaments, driven by a lyotropic liquid crystal (LC) intermediate phase. The results indicate anisotropic molecular alignment of the fluid phase, retention of the native secondary ...
Guido M. Merino, Matthew J. Harrington, Amy Szuchmacher Blum   +2 more
wiley   +1 more source

FXF‐OMe Is a Stable Tripeptide Motif for Ultra‐Short Peptide Coacervates That Establishes Structure‐Property‐Function Relationships

Small, EarlyView.
Ultra‐short peptides with a minimal sticker‐spacer structure undergo liquid‐liquid phase separation, resulting in condensates with microenvironments controlled by the hydrophobicity of the spacers. The condensates provide an easily tunable and exceptionally stable scaffold for photocatalytic microreactors in aqueous media, where catalysis efficiency is
Samuel Hamroff, Lucas Caire da Silva
wiley   +1 more source