Results 81 to 90 of about 10,769 (286)

Data of "Observations on hygroscopic growth and phase transitions of 1, 2, 6-hexanetriol/(NH4)2SO4 mixed particles: Investigation of liquid-liquid phase separation (LLPS) dynamic process and mechanism and secondary LLPS"

, 2020
The experimental data for "Observations on hygroscopic growth and phase transitions of 1, 2, 6-hexanetriol/(NH4)2SO4 mixed particles: Investigation of liquid-liquid phase separation (LLPS) dynamic process and mechanism and secondary ...
Pang, Shufeng, Ma, Shuaishuai, Chen, Zhe, Zhang, Yunhong   +3 more
core   +1 more source

Uncovering a new phase: the interactions that mediate MBD2 and MBD3 LLPS [PDF]

, 2023
Chromatin structure and organization controls DNA's accessibility to regulatory factors and influences gene regulation. Heterochromatin, or condensed chromatin containing mostly silenced genes, self-assembles through weak, multivalent interactions with ...
Maurici, Nicole
core  

A Protocol for Regulating Protein Liquid–Liquid Phase Separation Using NMR-Guided Mutagenesis

Methods and Protocols
Liquid–liquid phase separation (LLPS) underlies the formation of membraneless cellular compartments, yet experimental strategies that directly connect quantitative LLPS behavior with residue-level structural information remain limited.
Mayu Enomoto-Kusano, Kyoko Furuita, Takashi S. Kodama, Chojiro Kojima   +3 more
doaj   +1 more source

PPMC-lab/llps-datasets: v.1.1

Proteins self-organize in dynamic cellular environments by assembling into reversible biomolecular condensates through liquid-liquid phase separation (LLPS). These condensates can comprise single or multiple proteins, with different roles in the ensemble'
Bárcenas, Oriol, Pintado-Grima, Carlos, Arribas-Ruiz, Eva, Iglesias, Valentín, Burdukiewicz, Michał, Ventura, Salvador   +5 more
core   +1 more source

Programmed Interfacial Phase Separation for Spatiotemporal Fungicide Delivery via Tunable Micro/Nano Architectures

Advanced Science, EarlyView.
ABSTRACT Translating dynamic liquid‐liquid phase separation into robust solid‐state architectures remains a challenge in materials engineering. Here, we report a composition‐driven interfacial assembly strategy that couples supramolecular coacervation with metal‐phenolic coordination to engineer tunable fungicide carriers.
Rui Zhang, Tongfang Jing, Leiming He, Kaidi Cui, Yuying Song, Xuewei Mao, Lidong Cao, Lin Zhou   +7 more
wiley   +1 more source

Modeling liquid-liquid phase separation and its impact on proteasomal substrate degradation

Computational and Structural Biotechnology Journal
The proteasome, central to ubiquitin-proteasome mediated degradation of substrate proteins, undergoes liquid-liquid phase separation (LLPS) during substrate processing.
Di Wu, Qi Ouyang, Hongli Wang
doaj   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Phase separation of a PKA type I regulatory subunit regulates β-cell function through cAMP compartmentalization.

PLoS Biology
Cyclic adenosine monophosphate (cAMP), a ubiquitous second messenger, regulates a variety of cellular functions with high specificity. We previously showed that the type I regulatory subunit of cAMP-dependent protein kinase A (PKA), RIα, undergoes liquid-
Ha Neul Lee, Julia C Hardy, Emily H Pool, Jin-Fan Zhang, Su Hyun Kim, William F Buhl, Jessica G H Bruystens, Sohum Mehta, Susan S Taylor, Jin Zhang   +9 more
doaj   +1 more source

Long-lived proteins and DNA as candidate predictive biomarkers for tissue associated diseases

iScience
Summary: Protein turnover is an important mechanism to maintain proteostasis. Long-lived proteins (LLPs) are vulnerable to lose their function due to time-accumulated damages.
Xiaosong Liu, Bozidar Novak, Christian Namendorf, Barbara Steigenberger, Yaoyang Zhang, Christoph W. Turck   +5 more
doaj   +1 more source

The advent of the LLP in India

, 2015
In 2008, India passed a ground-breaking law to introduce the Limited Liability Partnership form into Indian business law. The Indian LLP Act was the first major introduction of a new business form in India in over 50 years. While the partnership and corporate forms (i.e.
openaire   +3 more sources