Results 101 to 110 of about 10,769 (286)

FAM81A facilitates LLPS of postsynaptic proteins in vitro.

(A) Confocal microscopic images of LLPS of FAM81A with PSD-95, GluN2B carboxyl tail, and SynGAP1. iFluor 488-labeled PSD-95, NirFP-labeled GluN2B, and iFluor 405-labeled SynGAP1 (3 μm each) were mixed with increasing concentrations (0, 1, and 3 μm) of ...
Taisei Hirouchi (18121663), Toru Takumi (72606), Takeo Saneyoshi (701663), Mark O. Collins (10944312), Toshihiko Shirafuji (847544), Takeshi Kaizuka (775489), Seth G. N. Grant (11820940), Yasunori Hayashi (701664)   +7 more
core   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

Role of liquid–liquid phase separation in cancer: Mechanisms and therapeutic implications

Cancer Innovation
Liquid–liquid phase separation (LLPS) has emerged as a pivotal biological phenomenon involved in various cellular processes, including the formation of membrane‐less organelles and the regulation of biomolecular condensates through precise spatiotemporal
Xuesong Li, Zhuo Yu
doaj   +1 more source

TDP-43 Liquid-Liquid Phase Separation (LLPS) Deficiency Attenuates Amyloid Beta Deposition in the 5XFAD Transgenic Mouse Model of Alzheimer\u27s Disease [PDF]

, 2021
Background: TAR DNA-binding protein 43 (TDP-43) can be found within the cell nucleus in most tissues and is a fundamental component to protein production, as it works to slice and reconfigure mRNA molecules.
Ren, Xiaojia, Wang, Luwen, Dunn, Justin, Ramachandran, Nathan, Gao, Ju, Wang, Xinglong, Peters, Ariele   +6 more
core  

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

Advanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri, A. Mangiarotti, C. N. Z. Schmitt, R. Dimova   +3 more
wiley   +1 more source

Integration of single-cell and bulk RNA sequencing data to identify liquid–liquid phase separation-related prognostic biomarkers in hepatocellular carcinoma

Scientific Reports
Liquid–liquid phase separation (LLPS) has been linked to the initiation and progression of cancers. This study aimed to investigate the LLPS-related molecular features and develop a prognostic signature for hepatocellular carcinoma (HCC). Single-cell RNA
Yanjun Luo, Xiaoming Wang
doaj   +1 more source

A pH-Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti-senescence. [PDF]

Smart Mol
Acidic pH triggers GOT1 phase separation via IDR1, recruiting ME1 to form ROS‐scavenging condensates that combat senescence, revealed by a FLIM‐based pH probe. Abstract Cellular senescence involves progressive acidification, but how cells sense and adapt to this pH shift remains unclear.
Chen Z, Li J, Bao Y, Wang M, Chen H, Zhang M, Ding L, Wu S, Shen B.   +8 more
europepmc   +2 more sources

Incomplete climate‐driven peripatric speciation in Moehringia sect. Moehringia (Caryophyllaceae) in the European Alps

American Journal of Botany, EarlyView.
Abstract Premise The origin of endemic species in the European Alps is commonly attributed to the climatic oscillations of the Quaternary. Moehringia sect. Moehringia, with 12 of 15 species endemic to the Alps and mostly restricted to well‐known glacial refugia, is a prime system for investigating the diversification of a lineage originating in the ...
Joachim W. Kadereit, Kirra McLeod, Audie M. Putra, Gudrun Kadereit, Diego F. Morales‐Briones   +4 more
wiley   +1 more source

Genetic and population analyses implicate thyroid‐related regulation of RNF144B in chondrocalcinosis

Arthritis &Rheumatology, Accepted Article.
Objectives Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5–15% of the general population and has recently been identified as an osteoarthritis risk factor. However, Its biological pathways remain unclear.
Yahong Wu, Yanning Xu, Paul C. Okoro, Sirine Saafi, Jard de Vries, Xiaoyi Qi, Edwin H.G. Oei, Sita Bierma‐Zeinstra, Trudy Voortman, David Felson, Joyce BJ van Meurs, Layal Chaker, J. Mark Wilkinson, Michelle S. Yau, Jessica Bertrand, Cindy G. Boer   +15 more
wiley   +1 more source

Antidepressant Prescribing Trends for Adults With and Without Autism in the United Kingdom From 1997 to 2023: A Population‐Based Cohort Study Using Clinical Practice Research Datalink Aurum

Autism Research, EarlyView.
ABSTRACT Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non‐autistic males and females in the United Kingdom (UK) from 1997 to 2023.
Aws Sadik, Golam M. Khandaker, Antonio F. Pardiñas, Michael Lundberg, Brian K. Lee, Cecilia Magnusson, Dheeraj Rai, Paul Madley‐Dowd   +7 more
wiley   +1 more source