Results 51 to 60 of about 4,772 (187)

A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected].

PLoS Genetics, 2014
Mutations in the LIM-homeodomain transcription factor LMX1B cause nail-patella syndrome, an autosomal dominant pleiotrophic human disorder in which nail, patella and elbow dysplasia is associated with other skeletal abnormalities and variably nephropathy
Sally H Cross, Danilo G Macalinao, Lisa McKie, Lorraine Rose, Alison L Kearney, Joe Rainger, Caroline Thaung, Margaret Keighren, Shalini Jadeja, Katrine West, Stephen C Kneeland, Richard S Smith, Gareth R Howell, Fiona Young, Morag Robertson, Rob van T' Hof, Simon W M John, Ian J Jackson   +17 more
doaj   +1 more source

Fine mapping of bone structure and strength QTLs in heterogeneous stock rat [PDF]

, 2015
We previously demonstrated that skeletal structure and strength phenotypes vary considerably in heterogeneous stock (HS) rats. These phenotypes were found to be strongly heritable, suggesting that the HS rat model represents a unique genetic resource for
Alam, Imranul, Baud, Amelie, Blázquez, Gloria, Cañete, Toni, Diez, Margarita, Díaz-Morán, Sira, Econs, Michael J., Fernández-Teruel, Alberto, Foroud, Tatiana, Johannesson, Martina, Koller, Daniel L., López-Aumatell, Regina, Martínez-Membrives, Esther, Mont-Cardona, Carme, Olsson, Tomas, Stridh, Pernilla, Tobeña, Adolf   +16 more
core   +1 more source

The limb dorsoventral axis: Lmx1b's role in development, pathology, evolution, and regeneration. [PDF]

Dev Dyn
Abstract The limb anatomy displays well‐defined dorsal and ventral compartments, housing extensor, and flexor muscles, which play a crucial role in facilitating limb locomotion and manipulation. Despite its importance, the study of limb dorsoventral patterning has been relatively neglected compared to the other two axes leaving many crucial questions ...
Castilla-Ibeas A, Zdral S, Oberg KC, Ros MA.   +3 more
europepmc   +2 more sources

Evidence for gliadin antibodies as causative agents in schizophrenia. [PDF]

, 2010
Antibodies to gliadin, a component of gluten, have frequently been reported in schizophrenia. Highly immunogenic B cell epitopes along its length are homologous to numerous proteins relevant to schizophrenia, including members of the DISC1 interactome ...
Chris J. Carter
core   +2 more sources

Spatial and temporal mechanisms of cell fate determination in the developing CNS [PDF]

, 2011
The generation of neural cell diversity in the developing central nervous system relies on mechanisms that provide spatial and temporal information to neural progenitor cells.
Dias, José
core   +1 more source

LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer

Journal of Immunology Research, 2022
Prostate cancer (PCa) is the most common cancer affecting men, with increasing global mortality and morbidity rates. Despite the progress in the diagnosis and treatment of PCa, patient outcomes remain poor, and novel therapeutic targets for PCa are ...
Min Meng, Yi-chen Wu
doaj   +1 more source

Sox, Fox, and Lmx1b binding sites differentially regulate a Gdf5-Associated regulatory region during elbow development

Frontiers in Cell and Developmental Biology, 2023
Introduction: The articulating ends of limb bones have precise morphology and asymmetry that ensures proper joint function. Growth differentiation factor 5 (Gdf5) is a secreted morphogen involved in cartilage and bone development that contributes to the ...
Ruth-Love Yeboah, Charmaine U. Pira, Matthew Shankel, Allen M. Cooper, Endika Haro, Van-Dai Ly, Kenrick Wysong, Michael Zhang, Nicole Sandoval, Kerby C. Oberg   +9 more
doaj   +1 more source

Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity

eLife, 2022
Assembly of transcriptomes encoding unique neuronal identities requires selective accessibility of transcription factors to cis-regulatory sequences in nucleosome-embedded postmitotic chromatin.
Xinrui L Zhang, William C Spencer, Nobuko Tabuchi, Meagan M Kitt, Evan S Deneris   +4 more
doaj   +1 more source

The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord [PDF]

, 2013
Dorsal horn neurons in the spinal cord integrate and relay sensory information to higher brain centers. These neurons are organized in specific laminae and different transcription factors are involved in their specification.
Bellocchio, Ben-Ari, Bermingham, Bouillet, Briscoe, Brown, Brown, Buckley, Burroughs-Garcia, Caspary, Chen, Cheng, Chiang, Chotteau-Lelièvre, Cui, Dickenson, Escurat, Fremeau, Ganguly, Glasgow, Goulding, Gowan, Graham, Gross, Guo, Hatcher, Helms, Honda, Irwin, John, Kaneko, Larsson, Le Mouellic, Lee, Leonardo, Lewis, Lin, Magin, Malcangio, Melzack, Müller, Nagy, Niss, Ozaki, Ramírez-Solis, Rebelo, Rexed, Rhinn, Rhinn, Rhinn, Rhinn, Robertson, Shamim, Sibilla, Simeone, Somogyi, Stein, Todd, Wassarman, Waters, Waters, White, Willis   +62 more
core   +3 more sources

Functional Characterization of LMX1B Mutations Associated with Nail-Patella Syndrome [PDF]

Pediatric Research, 2005
Nail-patella syndrome (NPS) is an autosomal dominant disease characterized by dysplastic nails, absent or hypoplastic patellae, elbow dysplasia, and nephropathy. Recently, it was shown that NPS is the result of heterozygous mutations in the LIM-homeodomain gene, LMX1B.
Utako, Sato, Sachiko, Kitanaka, Takashi, Sekine, Shori, Takahashi, Akira, Ashida, Takashi, Igarashi   +5 more
openaire   +2 more sources