Results 71 to 80 of about 4,772 (187)
Frontiers in Cell and Developmental Biology, 2020 Assembly of the ocular anterior segment (AS) is a critical event during development of the vertebrate visual system. Failure in this process leads to anterior segment dysgenesis (ASD), which is characterized by congenital blindness and predisposition to ...
Kristyn L. Van Der Meulen +4 more
doaj +1 more source
Miscellanea. Könyvismertetés [PDF]
, 2015 Könyvismertetés. J. R.Nunley, E. V. Lerma (Eds.): Dermatological manifestations of kidney disease Springer-Verlag New York, 2015 267 oldal ISBN 978-1-4939-2394-
Schneider, Imre
core +1 more source
Polydopamine‐Based Antioxidant Countermeasures Against Spaceflight‐Induced Neurodegeneration
Small Science, Volume 6, Issue 1, January 2026.Polydopamine nanoparticles (PDNPs) protect neuron‐like cells from microgravity‐ and cosmic radiation‐induced oxidative stress. Through in‐flight and ground‐based experiments, it has been shown that PDNPs preserve neuronal and mitochondrial function, markedly mitigating transcriptional dysregulation caused by spaceflight.
Alessio Carmignani +10 more
wiley +1 more source
A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord [PDF]
, 2014 The proper balance of excitatory and inhibitory neurons is crucial for normal processing of somatosensory information in the dorsal spinal cord. Two neural basic helix-loop-helix transcription factors (TFs), Ascl1 and Ptf1a, have contrasting functions in
Borromeo, M. D. +6 more
core +2 more sources
Mutation Analysis of LMX1B Gene in Nail-Patella Syndrome Patients [PDF]
The American Journal of Human Genetics, 1998 Nail-patella syndrome (NPS), a pleiotropic disorder exhibiting autosomal dominant inheritance, has been studied for >100 years. Recent evidence shows that NPS is the result of mutations in the LIM-homeodomain gene LMX1B. To determine whether specific LMX1B mutations are associated with different aspects of the NPS phenotype, we screened a cohort of 41 ...
McIntosh, Iain +14 more
openaire +2 more sources
The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development [PDF]
, 2003 LIM homeobox family members regulate a variety of cell fate choices during animal development. In C. elegans, mutations in the LIM homeobox gene lin-11 have previously been shown to alter the cell division pattern of a subset of the 2° lineage vulval ...
Gupta, Bhagwati P. +2 more
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The Role of Lmx1a and Lmx1b in Regulating Mesencephalon Development and Dopamine Neuron Specification [PDF]
, 2010 One of the most challenging questions in developmental biology is how neurons are specified, acquire their distinct characteristics and find their correct innervations to form functional circuits.
Deng, Qiaolin
core
The zebrafish eye—a paradigm for investigating human ocular genetics [PDF]
, 2016 Although human epidemiological and genetic studies are essential to elucidate the aetiology of normal and aberrant ocular development, animal models have provided us with an understanding of the pathogenesis of multiple developmental ocular malformations.
Moosajee, M +3 more
core +1 more source
Genetics of Common Obesity in Children and Adolescents
Annals of the New York Academy of Sciences, Volume 1553, Issue 1, Page 34-49, November 2025.Abstract Childhood obesity is a multifactorial public health problem worldwide. Genetic variation influences the predisposition to develop obesity at early stages of life. Childhood obesity may be classified as syndromic, monogenic, or polygenic depending on the genetic component.
Guadalupe León‐Reyes +2 more
wiley +1 more source
Nail-patella-like renal disease masquerading as Fabry disease on kidney biopsy: a case report
BMC Nephrology, 2020 Background Genetic changes in the LIM homeobox transcription factor 1 beta (LMX1B) have been associated with focal segmental glomerulosclerosis (FSGS) without the extra-renal or ultrastructural manifestations of Nail-patella syndrome (NPS) known as Nail ...
Filippo Pinto e Vairo +7 more
doaj +1 more source