Results 191 to 200 of about 112,460 (239)
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Improved Synthesis of 2′‐Amino‐LNA
ChemInform, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Christensen, S.M. +5 more
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Improvement of a streptavidin-binding aptamer by LNA- and α-l-LNA-substitutions
Bioorganic & Medicinal Chemistry Letters, 2014Forty modified versions of a streptavidin-binding aptamer each containing single or multiple LNA or α-l-LNA-substitutions were synthesized and their dissociation constants determined by surface plasmon resonance experiments. Both full-length and truncated versions of the aptamer were studied and compared with the unmodified DNA aptamers.
Jørgensen +4 more
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Structural Characterization of LNA and α‐L‐LNA Hybridized to RNA
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Michael Petersen +4 more
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Two-dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex
Chemical Communications, 2006We measured the helical repeats of a non-natural nucleic acid, locked nucleic acid (LNA), by incorporating LNA strands into the outer arms of a DNA double crossover (DX) molecule; atomic force microscopy (AFM) imaging of the two-dimensional (2D) arrays self-assembled from these DX molecules allows us to derive the helical repeat of the LNA/DNA hetero ...
Sherri, Rinker, Yan, Liu, Hao, Yan
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In Vitro Incorporation of LNA Nucleotides
Nucleosides, Nucleotides & Nucleic Acids, 2007An LNA modified nucleoside triphosphate 1 was synthesized in order to investigate its potential to act as substrate for DNA strand synthesis by polymerases. Primer extension assays for the incorporation experiments revealed that Phusion High Fidelity DNA polymerase is an efficient enzyme for incorporation of the LNA nucleotide and for extending strand ...
Veedu, R.N., Vester, B., Wengel, J.
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Aptamers as a model for functional evaluation of LNA and 2′-amino LNA
Bioorganic & Medicinal Chemistry Letters, 2009The affinity change upon incorporation of LNA and 2'-amino-LNA monomers into an avidin binding DNA aptamer is described. The kinetic profile of selected modified-aptamer was obtained by surface plasmon resonance experiments and compared with the profile of the parent unmodified DNA aptamer.
Hernandez, Frank J. +3 more
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2012
The main design goals of an LNA are to achieve low noise figure, high gain, good linearity and good matching and reverse isolation. The choice of the LNA topology is therefore very important to suit the design application. Five LNA topologies were studied, analyzed and compared in this chapter.
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The main design goals of an LNA are to achieve low noise figure, high gain, good linearity and good matching and reverse isolation. The choice of the LNA topology is therefore very important to suit the design application. Five LNA topologies were studied, analyzed and compared in this chapter.
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A 35 GHz monolithic MESFET LNA
IEEE 1988 Microwave and Millimeter-Wave Monolithic Circuits Symposium. Digest of Papers., 2003The design and fabrication of a state-of-the-art 35-GHz monolithic low-noise amplifier (LNA) is briefly described. The amplifier, with 6.5-dB gain, 4-dB noise figure, and 10-dBm power output at 1-dB gain compression, is based on a 0.25- mu m*200- mu m molecular-beam epitaxy (MBE)-grown MESFET.
S. Bandla +6 more
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X-band Monolithic Series Feedback LNA
MTT-S International Microwave Symposium Digest, 1985An X-band monolithic three-stage low noise amplifier (LNA) employing series feedback has demonstrated 1.8 dB noise figure with 30.0 dB gain and an input VSWR less than 1.2:1 at 10 GHz. The key to this design is using monolithic technology to obtain an exactly repeatable series feedback inductance to achieve a simultaneous noise match and input VSWR ...
R.E. Lehmann, D.D. Heston
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LNA noise parameter measurement
2015 European Conference on Circuit Theory and Design (ECCTD), 2015Joint measurement of stochastic parameters of a low noise amplifier (LNA), based on output power measurement for input termination impedances is considered. As an advantage of this method the noise parameters can be determined in a quick way for narrow and broad band applications without special equipment.
Bernhard Lehmeyer +2 more
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