Results 81 to 90 of about 117,740 (287)

Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals

open access: yesMolecular Therapy: Nucleic Acids, 2012
We report the structure activity relationships of short 14-mer phosphorothioate gapmer antisense oligonucleotides (ASOs) modified with α-L-locked nucleic acid (LNA) and related modifications targeting phosphatase and tensin homologue (PTEN) messenger RNA
Punit P Seth   +5 more
doaj   +1 more source

Eicosapentaenoic and Docosahexaenoic Acid Levels in Mouse Tissues After Intake of Echium and Ahiflower Oils Rich in Stearidonic and α‐Linolenic Acids

open access: yesLipids, EarlyView.
Dietary supplementation with stearidonic acid–rich Echium and Ahiflower oils increases EPA levels across multiple mouse tissues, while DHA responses remain tissue‐specific and limited, supporting the strategic use of plant‐based omega‐3 sources for EPA‐focused interventions. ABSTRACT Omega‐3 fatty acids (n‐3 FA), particularly eicosapentaenoic acid (EPA)
Letícia V. Segre   +2 more
wiley   +1 more source

Upregulated liver conversion of α-linolenic acid to docosahexaenoic acid in rats on a 15 week n-3 PUFA-deficient diets⃞

open access: yesJournal of Lipid Research, 2007
We quantified incorporation rates of plasma-derived α-linolenic acid (α-LNA, 18:3n-3) into “stable” liver lipids and the conversion rate of α-LNA to docosahexaenoic acid (DHA, 22:6n-3) in male rats fed, after weaning, an n-3 PUFA-adequate diet (4.6% α ...
Miki Igarashi   +5 more
doaj   +1 more source

Coaxial Dipole Array With Switching Transmit Sensitivities for Ultrahigh Field MRI

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To investigate dipole antennas with electronically switchable transmit field patterns to improve flip angle homogeneity in ultra‐high field MRI. Methods Reconfigurable dipole elements that could produce two distinct electronically switchable B1+$$ {B}_1^{+} $$ field profiles were conceptualized and constructed. Eight such elements were
Dario Bosch   +5 more
wiley   +1 more source

Localized Lna Cooling in Vacuum

open access: yes, 2006
In the Square Kilometre Array (SKA) telescope [1], [2], the noise temperature of the first LNA must be reduced in order to reduce the necessary active area and the total system costs. Cooling the LNA locally would significantly decrease the noise figure but also the necessary power since not the whole system has to be cooled.
Schreuder, F., Bij de Vaate, J.-G.
openaire   +3 more sources

A 2.2 μW analog front-end for multichannel neural recording [PDF]

open access: yes, 2017
In this paper an analog front-end for the multi-channel implantable recording of neural signals is presented. It is comprised by a two-stage AC-coupled low-noise amplifier (LNA) and a one stage AC-coupled variable gain amplifier (VGA).
Delgado Restituto, Manuel   +2 more
core   +1 more source

Stabilized Cellulase in Chitosan–Polyvinyl Alcohol Biopolymer Beads for Sustainable Enzymatic Deinking of Recycled Paper

open access: yesChemistryOpen, EarlyView.
A stable and reusable biocatalyst, cellulase@Cs/PVA/Ga, is engineered by immobilizing cellulase onto glutaraldehyde‐activated chitosan (Cs) and coating it with polyvinyl alcohol. This composite system enhances enzymatic stability and efficiency for the sustainable deinking of recycled newspaper, offering a green alternative to harsh chemical treatments.
Parisa Chakeri   +4 more
wiley   +1 more source

Locked nucleic acid as a novel class of therapeutic agents [PDF]

open access: yes, 2009
Locked Nucleic Acid (LNA) is a nucleic acid analogue with unprecedented binding affinity and excellent specificity toward complementary RNA and DNA oligonucleotides.
Veedu, Rakesh N., Wengel, Jesper
core   +2 more sources

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