Results 31 to 40 of about 48,734 (209)

A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA

Genome Biology, 2023
Background Extensive studies have revealed the function and mechanism of lncRNAs in development and differentiation, but the majority have focused on those lncRNAs adjacent to protein-coding genes.
Pei Lu, Jie Yang, Mao Li, Shanshan Wen, Tianzhe Zhang, Chenchao Yan, Ran Liu, Yu Xiao, Xinghuan Wang, Wei Jiang   +9 more
doaj   +1 more source

Prediction of lncRNA-protein interactions using HeteSim scores based on heterogeneous networks

Scientific Reports, 2017
Massive studies have indicated that long non-coding RNAs (lncRNAs) are critical for the regulation of cellular biological processes by binding with RNA-related proteins.
Yun Xiao, Jingpu Zhang, Lei Deng
doaj   +1 more source

Long Noncoding RNA MEG3-205/Let-7a/MyD88 Axis Promotes Renal Inflammation and Fibrosis in Diabetic Nephropathy

Kidney Diseases, 2022
Aim: The aim of this study was to investigate the role and mechanism of long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3)-205 in renal inflammation and fibrosis in diabetic nephropathy (DN). Materials and Methods: lncRNA microarray profiling
Qimei Luo, Xi Xia, Qingqing Luo, Yue Qiu, Lan Dong, Chen Zhao, Fenfen Peng, Jing Yu, Fengxian Huang, Feng He   +9 more
doaj   +1 more source

Gene Ontology-based function prediction of long non-coding RNAs using bi-random walk

BMC Medical Genomics, 2018
Background With the development of sequencing technology, more and more long non-coding RNAs (lncRNAs) have been identified. Some lncRNAs have been confirmed that they play an important role in the process of development through the dosage compensation ...
Jingpu Zhang, shuai Zou, Lei Deng
doaj   +1 more source

Altered long noncoding RNA profile after intracerebral hemorrhage

Annals of Clinical and Translational Neurology, 2019
Objective We investigated the expression pattern of long noncoding RNAs (lncRNA) and messenger RNAs (mRNA) from two different intracerebral hemorrhage (ICH) rat models, and performed gene ontology and gene/protein interaction analyses.
Jeong‐Min Kim, Jangsup Moon, Jung‐Suk Yu, Dong‐Kyu Park, Soon‐Tae Lee, Keun‐Hwa Jung, Kon Chu   +6 more
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Integrated analyses of long noncoding RNAs and mRNAs in the progression of breast cancer

Journal of International Medical Research, 2021
Objective The objective was to explore the expression and potential functions of long noncoding RNA (lncRNA) and mRNAs in human breast cancer (BC). Methods Differentially expressed lncRNAs and mRNAs were identified and annotated in BC tissues by using ...
Jingyun Guo, Huining Lian, Minfeng Liu, Jianyu Dong, Zhaoze Guo, Jinlamao Yang, Changsheng Ye   +6 more
doaj   +1 more source

The binding of lncRNA RP11-732M18.3 with 14-3-3 β/α accelerates p21 degradation and promotes glioma growthResearch in context

EBioMedicine, 2019
Background: Long noncoding RNAs (lncRNAs) have been identified as regulators of a number of developmental and tumorigenic processes. However, the functions of most lncRNAs in glioma remain unknown and the mechanisms governing the proliferation of tumor ...
Chun-Min Kang, Huan-Lan Bai, Xue-Heng Li, Rui-Ying Huang, Jing-Jing Zhao, Xiao-Yan Dai, Lei Zheng, Yu-Rong Qiu, Yan-Wei Hu, Qian Wang   +9 more
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Structural Modifications and Novel Protein-Binding Sites in Pre-miR-675—Explaining Its Regulatory Mechanism in Carcinogenesis

Non-Coding RNA, 2023
Pre-miR-675 is a microRNA expressed from the exon 1 of H19 long noncoding RNA, and the atypical expression of pre-miR-675 has been linked with several diseases and disorders including cancer. To execute its function inside the cell, pre-miR-675 is folded
Abhishek Dey
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LncRNA-TBP mediates TATA-binding protein recruitment to regulate myogenesis and induce slow-twitch myofibers

Cell Communication and Signaling, 2023
Background Skeletal muscle is comprised of heterogeneous myofibers that differ in their physiological and metabolic parameters. Of these, slow-twitch (type I; oxidative) myofibers have more myoglobin, more mitochondria, and higher activity of oxidative ...
Manting Ma, Bolin Cai, Zhen Zhou, Shaofen Kong, Jing Zhang, Haiping Xu, Xiquan Zhang, Qinghua Nie   +7 more
doaj   +1 more source

LPI-KTASLP: Prediction of LncRNA-Protein Interaction by Semi-Supervised Link Learning With Multivariate Information

IEEE Access, 2019
Long non-coding RNA, also known as lncRNA, is a series of single-stranded polynucleotides (no less than 200 nucleotides each), consisting of non-protein coding transcripts.
Cong Shen, Yijie Ding, Jijun Tang, Limin Jiang, Fei Guo   +4 more
doaj   +1 more source