Results 91 to 100 of about 103,530 (319)

Over two decades of research on the marine RNA virosphere

iMeta, Volume 1, Issue 4, December 2022., 2022
Advances in meta‐omics provide a surge of marine RNA virus information. Deep marine virus discovery contributes greatly to the megataxonomy of RNA viruses. Understanding diversity and biogeography helps reveal the significance of marine RNA viruses, including evolutionary trajectories, hierarchical taxonomy, and ecological importance.
Meng‐en Liao, Yunyi Xie, Mang Shi, Jie Cui   +3 more
wiley   +1 more source

Evaluation of NKILA lncRNA and NFκB Genes Expression in an Iranian Gastric Cancer Patient Compared with Healthy Tissue and the Relationship between Clinicopathological Features [PDF]

Journal of Advanced Biomedical Sciences, 2022
Background & Objective: Long non-coding RNAs play critical roles in the initiation and development of gastric cancer (GC). The aim of this study was to assess the expression of NKILA and NFKB genes and the relationship between their expressions with ...
Negar Soltani, Leila Pishkar, Vahid Chaleshi   +2 more
doaj  

Role of lncRNAs in Cellular Aging [PDF]

Frontiers in Endocrinology, 2016
Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate cellular processes including cellular senescence, telomere shortening, stem cell exhaustion, mitochondrial dysfunction, and deregulated metabolism. Cellular senescence is accepted as one of the core processes of aging at the organism level.
Lei Sun, Lei Sun, Ufuk Degirmenci, Ufuk Degirmenci   +3 more
openaire   +5 more sources

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds

Advanced Science, EarlyView.
PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal, Pei Y. Liu, Janith Seneviratne, Antoine De Weck, Pooja Venkat, Chelsea Mayoh, Jing Wu, Jesper Maag, Jingwei Chen, Matthew Wong, Nenad Bartonicek, Poh Khoo, Lei Jin, Louise E. Ludlow, David S. Ziegler, Toby Trahair, Pieter Mestdagh, Belamy B. Cheung, Jinyan Li, Marcel E. Dinger, Ian Street, Xu D. Zhang, Glenn M. Marshall, Tao Liu   +23 more
wiley   +1 more source

miR‐96‐5p regulates cervical cancer cell resistance to cisplatin by inhibiting lncRNA TRIM52‐AS1 and promoting IGF2BP2

The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 12, Page 1178-1189, December 2022., 2022
Abstract MicroRNA (miRNA) and long noncoding RNA (lncRNA) are both regulators of cancer progression. This study sought to discuss the functional mechanism of miR‐96‐5p/lncRNA TRIM52 antisense RNA 1 (head‐to‐head; TRIM52‐AS1) in cervical cancer (CC) cell resistance to cisplatin (DDP).
En Yuesu Wu, Li‐Ping Huang, Jin‐Hua Bao   +2 more
wiley   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

LINC00960 regulates cell proliferation and glycolysis in pancreatic cancer through the miR‐326‐3p/TUFT1/AKT–mTOR axis

The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 12, Page 1155-1167, December 2022., 2022
Abstract Pancreatic cancer (PC) is a common malignant cancer characterized by high mortality and poor prognosis. LINC00690 was involved in the occurrence and progression of PC, but the underlying mechanisms require further investigation. The goal of this study was to figure out how LINC00960 mediates glycolysis in PC.
Bin Zhou, Jing‐Hao Lei, Qiang Wang, Teng‐Fei Qu, Li‐Chao Cha, Han‐Xiang Zhan, Shang‐Long Liu, Xiao Hu, Chuan‐Dong Sun, Jing‐Yu Cao, Fa‐Bo Qiu, Wei‐Dong Guo   +11 more
wiley   +1 more source

Revealing lncRNA Biomarkers Related to Chronic Obstructive Pulmonary Disease Based on Bioinformatics

International Journal of COPD, 2022
Hui Han, Lu Hao Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, People’s Republic of ChinaCorrespondence: Lu Hao, Area B, Department of Respiratory Medicine, Affiliated Hospital ...
Han H, Hao L
doaj  

Sperm‐Derived CircRNA‐1572 Regulates Embryogenesis and Zygotic Genome Activation by Targeting CCNB2 via Bta‐miR‐2478‐L‐2

Advanced Science, EarlyView.
Sperm‐derived circRNA‐1572 competitively binds to bta‐miR‐2478‐L‐2 through a “sponge” mechanism to regulate cyclin B2 (CCNB2) expression, thereby modulating the distribution of fibrous actin (F‐actin) in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage and zygotic genome activation.
Yanfang Wu, Yaochang Wei, Yuelin Li, Yiming Dou, YongQiang Yang, Hanghang Liu, Xiaoyan Wang, Zheng Wang, Jianmin Su, Yong Zhang, Yongsheng Wang   +10 more
wiley   +1 more source

Long noncoding RNA CDKN2B‐AS1 silencing protects against esophageal cancer cell invasion and migration by inactivating the TFAP2A/FSCN1 axis

The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 12, Page 1144-1154, December 2022., 2022
Abstract Esophageal cancer (EC) is the most aggressive malignancy in the gastrointestinal tract. Long noncoding RNA cyclin‐dependent kinase inhibitor 2 B antisense RNA 1 (CDKN2B‐AS1) is implicated in EC development. However, the specific mechanisms involved remain poorly defined.
Jia‐Liang Zhu, Wen‐Bo Xue, Zhi‐Bin Jiang, Wei Feng, Yi‐Cai Liu, Xiong‐Ying Nie, Long‐Yu Jin   +6 more
wiley   +1 more source