Results 91 to 100 of about 167,789 (348)

Harnessing adipogenesis to prevent obesity

Adipocyte, 2019
Obesity and associated metabolic complications, including diabetes, cardiovascular and hepatic diseases, and certain types of cancers, create a major socioeconomic burden.
Nida Haider, Louise Larose
doaj   +1 more source

m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1

Molecular Cancer, 2019
Long noncoding RNAs (lncRNAs) have emerged as critical players in cancer progression, but their functions in colorectal cancer (CRC) metastasis have not been systematically clarified.
Yingmin Wu, Xiangling Yang, Zhuojia Chen, Lin Tian, Guan-min Jiang, Feng Chen, Jiexin Li, Panpan An, Linlin Lu, Nan Luo, Jun Du, H. Shan, Huanliang Liu, Hongsheng Wang   +13 more
semanticscholar   +1 more source

Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis

Communications Biology, 2020
Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating the need for a resource of lncRNAs with validated cancer roles.
Joana Carlevaro-Fita, Andrés Lanzós, L. Feuerbach, Chen Hong, David Mas-Ponte, J. S. Pedersen, Federico Samirkumar B. Gary D. Jonathan Rameen Johanna Keit Abascal Amin Bader Barenboim Beroukhim Bertl Boroe, F. Abascal, S. Amin, Gary D Bader, J. Barenboim, R. Beroukhim, Johanna Bertl, Keith A. Boroevich, S. Brunak, P. Campbell, D. Chakravarty, Calvin Wing Yiu Chan, Ken Chen, J. Choi, J. Deu-Pons, P. Dhingra, K. Diamanti, L. Feuerbach, J. Fink, Nuno A. Fonseca, J. Frigola, C. Gambacorti-Passerini, D. Garsed, M. Gerstein, G. Getz, A. González-Pérez, Qianyun Guo, I. Gut, D. Haan, M. P. Hamilton, N. Haradhvala, A. Harmanci, M. Helmy, C. Herrmann, J. Hess, A. Hobolth, Ermin Hodzic, H. Hornshøj, Keren Isaev, J. Izarzugaza, Rory Johnson, Todd A. Johnson, Malene Juul, R. Juul, A. Kahles, A. Kahraman, Manolis Kellis, Ekta Khurana, Jaegil Kim, J. K. Kim, Youngwook Kim, J. Komorowski, J. Korbel, Sushant Kumar, Andrés Lanzós, E. Larsson, M. Lawrence, Donghoon Lee, K. Lehmann, Shantao Li, Xiaotong Li, Ziao Lin, E. M. Liu, L. Lochovsky, S. Lou, Tobias Madsen, K. Marchal, I. Martincorena, A. Martínez-Fundichely, Y. Maruvka, Patrick D. McGillivray, W. Meyerson, Ferran Muiños, L. Mularoni, H. Nakagawa, M. Nielsen, M. Paczkowska, Keunchil Park, Kiejung Park, O. Pich, T. Pons, Sergio Pulido-Tamayo, Benjamin J. Raphael, J. Reimand, I. Reyes-Salazar, M. Reyna, Esther Rheinbay, M. Rubin, C. Rubio-Perez, R. Sabarinathan, S. C. Sahinalp, G. Saksena, L. Salichos, C. Sander, S. Schumacher, M. Shackleton, Ofer Shapira, Ciyue Shen, Raunak Shrestha, S. Shuai, N. Sidiropoulos, L. Sieverling, Nasa Sinnott-Armstrong, Lincoln D. Stein, Joshua M. Stuart, D. Tamborero, G. Tiao, T. Tsunoda, Husen M. Umer, Liis Uusküla-Reimand, A. Valencia, M. Vázquez, L. Verbeke, C. Wadelius, Lina Wadi, Jiayin Wang, J. Warrell, Sebastian M. Waszak, Joachim Weischenfeldt, D. Wheeler, Guanming Wu, Jun Yu, Jing Zhang, Xuanping Zhang, Yan Zhang, Zhongming Zhao, L. Zou, C. von Mering, Rory Johnson   +134 more
semanticscholar   +1 more source

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

HAND2-AS1 Inhibits Gastric Adenocarcinoma Cells Proliferation and Aerobic Glycolysis via miRNAs Sponge

Cancer Management and Research, 2020
Zhiyuan Xu,1,* Hang Lv,2,* Yiping Wang,2 Can Hu,3 Shangqi Chen,3 Yian Du,1 Chengwei Shi,3 Xiangdong Cheng1 1Department of Gastric Surgery, Institute of Cancer and Basic Medicine, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang ...
Xu Z, Lv H, Wang Y, Hu C, Chen S, Du Y, Shi C, Cheng X   +7 more
doaj  

ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1

Journal of physiology and biochemistry, 2019
N6-Methyladenosine (m6A) is the most common posttranscriptional modification of RNA and plays critical roles in cancer pathogenesis. However, the biological function of long noncoding RNA (lncRNA) methylation remains unclear.
Jun Zhang, Shuai Guo, H. Piao, Yue Wang, Yue Wu, Xiang-yu Meng, Dong Yang, Zhi-chao Zheng, Yan Zhao   +8 more
semanticscholar   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus

Nature Communications, 2020
Long non-coding RNAs (lncRNAs) are emerging regulators of pathophysiological processes including atherosclerosis. Using RNA-seq profiling of the intima of lesions, here we identify a macrophage-specific lncRNA MAARS (Macrophage-Associated Atherosclerosis
Viorel Simion, Haoyang Zhou, S. Haemmig, Jacob B. Pierce, Shanelle Mendes, Yevgenia Tesmenitsky, D. Pérez-Cremades, James F. Lee, Alex F. Chen, N. Ronda, B. Papotti, J. Marto, M. W. Feinberg   +12 more
semanticscholar   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc

Nature Communications, 2019
Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown.
Jiayin Tang, Tingting Yan, Yujie Bao, Chao-qin Shen, Chenyang Yu, Xiaoqiang Zhu, Xianglong Tian, Fangfang Guo, Q. Liang, Qiang Liu, M. Zhong, Jinxian Chen, Z. Ge, Xiaobo Li, Xiaoyu Chen, Yun Cui, Yingxuan Chen, W. Zou, Haoyan Chen, Jie Hong, J. Fang   +20 more
semanticscholar   +1 more source