Results 111 to 120 of about 103,530 (319)

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Advanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang   +15 more
wiley   +1 more source

Inhibition of lncRNA PART1 Chemosensitizes Wild Type but Not KRAS Mutant NSCLC Cells

Cancer Management and Research, 2020
Shu-Chen Chen,1 Yu-Zhu Diao,1 Zi-Han Zhao,2 Xiao-Ling Li1 1Medical Oncology Department of Thoracic Cancer 1, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, Liaoning 110042, People’s Republic of China; 2The Second ...
Chen SC, Diao YZ, Zhao ZH, Li XL
doaj  

Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives

Cancer Management and Research, 2021
Peng Huang, Shaomi Zhu, Xin Liang, Qinxiu Zhang, Xiaohong Luo, Chi Liu, Linjiang Song Reproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s ...
Huang P, Zhu S, Liang X, Zhang Q, Luo X, Liu C, Song L   +6 more
doaj  

Erythropoietin‐Stimulated Macrophage‐Derived Extracellular Vesicles in Chitosan Hydrogel Rescue BMSCs Fate by Targeting EGFR to Alleviate Inflammatory Bone Loss in Periodontitis

Advanced Science, EarlyView.
A therapeutic strategy is proposed for periodontitis using extracellular vesicles derived from EPO‐stimulated macrophages (EPO‐EVs). This schema demonstrates how EPO‐EVs enhance the osteogenic activity of mBMSCs in an inflammatory environment by inhibiting EGFR.
Shuchen Liu, Zhuoran Wang, Yuhuan Li, Ziyi Pan, Lei Huang, Jing Cui, Xue Zhang, Mingxi Yang, Yuan Zhang, Daowei Li, Hongchen Sun   +10 more
wiley   +1 more source

Integrated Analysis of Altered lncRNA, circRNA, microRNA, and mRNA Expression in Hepatocellular Carcinoma Carrying TERT Promoter Mutations

Journal of Hepatocellular Carcinoma, 2022
Haibin Zhang,1 Xiaolu Zhang,1 Jingya Yu2 1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 2Department of Diagnostics ...
Zhang H, Zhang X, Yu J
doaj  

AKT1E17K‐Interacting lncRNA SVIL‐AS1 Promotes AKT1 Oncogenic Functions by Preferentially Blocking AKT1E17K Dephosphorylation

Advanced Science, EarlyView.
Wang et al. discover a novel lncRNA regulator of mutant oncoprotein which prevents AKT1E17K dephosphorylation. SVIL‐AS1 overexpression correlates with poor prognosis of breast cancer patients. It interacts with AKT1E17K protein and impedes PP2A holoenzyme from dephosphorylating AKT1 by blocking the binding of the regulatory subunit PPP2R2A to AKT1 ...
Jingyi Wang, Wenying Chen, Qianying Li, Ruiyi Yang, Xiaorong Lin, Ping Han, Xiaoming Huang, Hai Hu, Man‐Li Luo   +8 more
wiley   +1 more source

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles

Advanced Science, EarlyView.
Recent studies highlighted the heterogeneity of EVs and the influence of microenvironmental signals on their therapeutic efficacy. This review offers a comprehensive overview of strategies and mechanisms to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation.
Bilu Xiang, Shiying Zhang, Irene Shuping Zhao, Xueqi Gan, Yang Zhang   +4 more
wiley   +1 more source

SNORA74A Drives Self‐Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling

Advanced Science, EarlyView.
Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou, Yang Gu, Zhibin Yi, Jianyi Wang, Zhen Xiong, Hui Guo, Ying Du, Xiaoxiao Zhu, Lei He, Weizheng Ren, Yong Tian, Yanying Wang, Zusen Fan   +12 more
wiley   +1 more source

Expression of LOC285758, a potential long non-coding biomarker, is methylation-dependent and correlates with glioma malignancy grade

Radiology and Oncology, 2017
Identifying the early genetic drivers can help diagnose glioma tumours in their early stages, before becoming malignant. However, there is emerging evidence that disturbance of epigenetic mechanisms also contributes to cell’s malignant transformation and
Matjasic Alenka, Popovic Mara, Matos Bostjan, Glavac Damjan   +3 more
doaj   +1 more source