Results 191 to 200 of about 103,530 (319)

Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells

Movement Disorders, EarlyView.
Abstract Background The 17q21.31 region with various structural forms characterized by the H1/H2 haplotypes and three large copy number variations (CNVs) represents the strongest risk locus in progressive supranuclear palsy (PSP). Objective To investigate the association between CNVs and structural forms on 17q.21.31 with the risk of PSP.
Hui Wang, Timothy S. Chang, Beth A. Dombroski, Po‐Liang Cheng, Ya‐Qin Si, Albert Tucci, Vishakha Patil, Leopoldo Valiente‐Banuet, Chong Li, Kurt Farrell, Catriona Mclean, Laura Molina‐Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C. Van Swieten, Elise Dopper, Bernardino F. Ghetti, Kathy L. Newell, Claire Troakes, Justo G. de Yébenes, Alberto Rábano‐Gutierrez, Tina Meller, Wolfgang H. Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Müller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G. Beach, Geidy E. Serrano, Lili‐Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A. Ross, Douglas Galasko, Adam L. Boxer, Bruce L. Miller, Willian W. Seeley, Vivianna M. Van Deerlin, Edward B. Lee, Charles L. White III, Huw R. Morris, Rohan de Silva, John F. Crary, Alison M. Goate, Jeffrey S. Friedman, Yaroslau Compta, Yuk Yee Leung, Giovanni Coppola, Adam C. Naj, Li‐San Wang, PSP Genetics Study Group, Anthony E. Lang, Murray Grossman, David S. Knopman, Lon S. Schneider, Rachelle S. Doody, Andrew Lees, Lawrence I. Golbe, David R. Williams, Jean‐Cristophe Corvol, Albert Ludolph, David Burn, Stefan Lorenzl, Erik D. Roberson, Mary Koestler, Clifford R. Jack Jr, Christopher Randolph, Iryna V. Lobach, Hilary W. Heuer, Illana Gozes, Lesley Parker, Steve Whitaker, Joe Hirman, Alistair J. Stewart, Michael Gold, Bruce H. Morimoto, Jochen Herms, Ellen Gelpi, Clifton Dalgard, Dennis W. Dickson, Günter U. Höglinger, Jung‐Ying Tzeng, Daniel H. Geschwind, Gerard D. Schellenberg, Wan‐Ping Lee   +93 more
wiley   +1 more source

LncRNA transcriptome analysis of rainbow trout (<i>Oncorhynchus mykiss</i>) skin infected with IHNV reveals that lncRNA SARL/miR-205-z/<i>SOCS3</i> axis negatively regulates antiviral immunity mechanisms. [PDF]

Virulence
Zhao L, Huang J, Li Y, Wu S.
europepmc   +1 more source

The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins [PDF]

, 2015
Hasan Imam, Aalia Shahr Bano, Paresh D. Patel, Prasida Holla, Shahid Jameel   +4 more
openalex   +1 more source

LncRNA MRF targeting FSHR inhibits the osteogenic differentiation of BMSCs and bone defect repair through the regulation of the cAMP-PKA-CREB signaling pathway. [PDF]

Stem Cell Res Ther
Ning Q, Li M, Liao Z, Chen E, Liu H, Liang Y, Chen Y, Li Y, Huang L.   +8 more
europepmc   +1 more source

MicroRNAs and lncRNAs in senescence: A re‐view [PDF]

, 2015
Oliver Bischof, Ricardo Iván Martínez‐Zamudio   +1 more
openalex   +1 more source

Effects of Natural Polysaccharides on the Gut Microbiota Related to Human Metabolic Health

Molecular Nutrition &Food Research, EarlyView.
The graphical abstract illustrates the role of polysaccharides extracted from various natural raw materials (such as mushrooms, marine organisms, fruits, and vegetables) in modulating the gut microbiota. The process begins with the extraction and purification of polysaccharides, followed by assessing their structure‐activity relationship. Upon entering
Yigang Huang, Hongfei Guo, Yuchen Liu, Wengang Jin, Chella Perumal Palanisamy, Jinjin Pei, Fatih Oz, A. M. Abd El‐Aty   +7 more
wiley   +1 more source

The LncRNA RMST-miR-4295-ITPR1 axis: a key mechanism in regulating autophagy in triple-negative breast cancer cells. [PDF]

BMC Cancer
Zhang L, Li S, Shi J, Guo H, Wang B, Geng C.   +5 more
europepmc   +1 more source

Downregulation of lncRNA TUG1 Affects Apoptosis and Insulin Secretion in Mouse Pancreatic β Cells [PDF]

, 2015
Dandan Yin, Erbao Zhang, Lianghui You, Ning Wang, Lintao Wang, Xin Jin, Yanan Zhu, Lihua Cao, Qingxin Yuan, Wei De, Wei Tang   +10 more
openalex   +1 more source

Microfluidic Systems in Cancer Diagnosis: Advancing Exosome and CTC Detection From Laboratory Research to Clinical Application

Nano Select, EarlyView.
Detection of cancer through the identification of EV markers and CTCs using microfluidic systems is rapidly advancing. These markers are typically identified from liquid biopsy samples, which offer a highly favorable alternative to traditional biopsy methods due to their non‐invasive nature.
Bahareh Valinezhad Saghezi, Kamran Mansouri, Rahman Hallaj   +2 more
wiley   +1 more source

A Feedback Loop of LINC00665 and the Wnt Signaling Pathway Expedites Osteosarcoma Cell Proliferation, Invasion, and Epithelial‐Mesenchymal Transition

Orthopaedic Surgery, Volume 15, Issue 1, Page 286-300, January 2023., 2023
TCF/LEF transcription complex induced the up‐regulation of LINC00665 and LINC00665 promoted OS cell growth. Mechanistically, LINC00665 functioned as a ceRNA to modulate miR‐1249‐5p and thereby up‐regulate WNT2B to enhance the Wnt pathway and the expression of downstream genes, which formed a positive feedback loop.
Jinyu Bai, Xiao Zhang, Fengxian Jiang, Huajian Shan, Xiang Gao, Lin Bo, Yingzi Zhang   +6 more
wiley   +1 more source