Results 231 to 240 of about 103,530 (319)

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, EarlyView.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

LncRNA FTX promotes colorectal cancer radioresistance through disturbing redox balance and inhibiting ferroptosis <i>via</i> miR-625-5p/SCL7A11 axis. [PDF]

World J Gastroenterol
Dai Q, Qu TY, Yang JL, Leng J, Fang L, Zhu QQ, Wu KB, Wu J, Ma JJ, Yu HF.   +9 more
europepmc   +1 more source

Microarray expression profile of lncRNAs and the upregulated ASLNC04080 lncRNA in human endometrial carcinoma

, 2015
Wen Zhai, Xu Li, Shouzhen Wu, Yan Zhang, Huan Pang, Wei Chen   +5 more
openalex   +2 more sources

Lnc‐TPT1‐AS1/CBP/ATIC Axis Mediated Purine Metabolism Activation Promotes Breast Cancer Progression

Cancer Science, EarlyView.
Overexpression of TPT1‐AS1 could suppress the malignant phenotype and purine synthesis activation of breast cancer through competitive interaction with CBP, subsequently reducing the promoter H3K27ac signal and transcription of ATIC. Therefore, targeting the TPT1‐AS1/CBP/ATIC axis may provide a useful strategy for the treatment of patients with breast ...
Yiyun Zhang, Hanyu Zhang, Mingcui Li, Yanling Li, Zhuo‐Ran Wang, Weilun Cheng, Yansong Liu, Zhengbo Fang, Ang Zheng, Jingxuan Wang, Fei Ma   +10 more
wiley   +1 more source

Use of serum long non-coding RNA expression panel as a marker for diabetic retinopathy. [PDF]

Front Cardiovasc Med
Wang E, Chen S, Ali A, Feng B, Liu S, Gonder J, Sheidow T, Hooper P, Chakrabarti S.   +8 more
europepmc   +1 more source

Exosomal PKM2: A Noninvasive Diagnostic Marker Linking Macrophage Metabolic Reprogramming to Gastric Cancer Pathogenesis

Cancer Science, EarlyView.
Plasma exosomal PKM2 is a promising novel biomarker for early gastric cancer diagnosis. It activates the SREBP1‐mediated lipid synthesis pathway in macrophages, promoting their alternative activation and thereby driving tumor progression. ABSTRACT Tumor‐derived exosomes (TDEs) have emerged as vital biomarkers of multiple cancers.
Mengyun Yuan, Xiaoxia Zheng, Shanshan Zheng, Huaizhi Li, Xingxing Zhang, Yuxuan Chen, Xiang Zhang, Bo Han, Wei Wei, Jian Wu, Qingmin Sun   +10 more
wiley   +1 more source

lncRNA Ubr5 promotes BMSCs apoptosis and inhibits their proliferation and osteogenic differentiation in weightless bone loss. [PDF]

Front Cell Dev Biol
Wang D, Gao Y, Tan Y, Li N, Li X, Li J, Pan Y, Zhao X, Yan M, Wang Y.   +9 more
europepmc   +1 more source

Exploring Long Noncoding RNAs as Regulators of Tumor Ferroptosis: Advances and Challenges

Cancer Science, EarlyView.
Long noncoding RNAs (lncRNAs) play pivotal roles in regulating gene expression and are closely associated with cancer progression, prognosis, and therapeutic resistance. This review highlights recent advancements in understanding how lncRNAs modulate ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation ...
Gang Li, Bing Wang, Lisha Ye, Guohua Wang   +3 more
wiley   +1 more source

Novel Biological Strategies for Melanoma Therapy: A Focus on lncRNAs and Their Targeting. [PDF]

Cancers (Basel)
Orlandella FM, Arcone R, Luciano N, Salvatore G, Motti ML.   +4 more
europepmc   +1 more source

Inhibition of the long non-coding RNA MALAT1 downregulates MAP2K1, suppressing the progression of hypopharyngeal squamous cell carcinoma. [PDF]

Biomol Biomed
Wang X, Li H, Xu A, Peng J, Wu Y, Liu Y, Zhang J, Cai C, Ma S, Zhang K.   +9 more
europepmc   +1 more source