Results 251 to 260 of about 103,530 (319)

Mechanistic Insights and Therapeutic Potentials of Ubiquitin‐Proteasome System in Non‐Small Cell Lung Cancer

open access: yesCell Proliferation, EarlyView.
Lung cancer development involves mechanisms like reduced EGFR/EGF ubiquitination driving cancer cell behaviors and immune evasion via loss of PD‐1/PD‐L1 ubiquitination. Balancing ubiquitination and deubiquitination may be a potential therapeutic strategy. ABSTRACT Non‐small cell lung cancer (NSCLC) remains a leading cause of cancer mortality.
Guangyao Zhou   +5 more
wiley   +1 more source

Regulation of physiological and pathological condensates by molecular chaperones

open access: yesThe FEBS Journal, EarlyView.
Mounting evidence suggests that stress granules (SGs), dynamic membraneless compartments involved in cellular stress responses, can transition into pathological condensates upon improper disassembly. This review discusses the evidence supporting this notion.
Nadeen Akaree   +5 more
wiley   +1 more source

LncRNA analysis of mouse spermatogonial stem cells following glial cell-derived neurotrophic factor treatment

open access: gold, 2015
Lufan Li   +8 more
openalex   +1 more source

Physical and functional interactions between LDLR family members and CXCR4 in breast cancer

open access: yesThe FEBS Journal, EarlyView.
Here, we demonstrate that members of the low‐density lipoprotein receptor (LDLR) family can regulate C‐X‐C chemokine receptor type 4 (CXCR4) signaling and therefore affect CXCR4‐induced breast cancer metastasis. We found that very low‐density lipoprotein receptor (VLDLR), low‐density lipoprotein receptor‐related protein 8 (LRP8) and apolipoprotein E ...
Jiankang Zhang   +7 more
wiley   +1 more source

Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application

open access: yesThe FEBS Journal, EarlyView.
Multiple myeloma is characterised by the clonal proliferation of plasma cells in the bone marrow. Extracellular vesicles (EVs) are a key component of cell‐to‐cell communication within the bone marrow microenvironment, promoting tumour growth, bone remodelling, immune modulation, angiogenesis and therapeutic resistance.
Chloe Wylie   +3 more
wiley   +1 more source

Mechanism of action of lncRNA-NEAT1 in immune diseases. [PDF]

open access: yesFront Genet
Zhang RX   +6 more
europepmc   +1 more source

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