Results 51 to 60 of about 103,530 (319)
Blood-derived lncRNAs as potential biomarkers for early cancer diagnosis: The Good, the Bad and the Beauty [PDF]
arXiv, 2021 Cancer ranks as one of the deadliest diseases worldwide. The high mortality rate associated with cancer is partially due to the lack of reliable early detection methods and/or inaccurate diagnostic tools such as certain protein biomarkers. Cell-free nucleic acids (cfNA) such as circulating long non-coding RNAs (lncRNAs) have recently been proposed as a
arxiv
Identification and Construction of a Predictive Immune-Related lncRNA Signature Model for Melanoma
International Journal of General Medicine, 2021 Fang-Wei Li, Sheng-Kang Luo Department of Plastic and Reconstructive Surgery, Guangdong Second Provincial General Hospital, Guangzhou City, Guangdong Province, 510317, People’s Republic of ChinaCorrespondence: Sheng-Kang LuoDepartment of Plastic and ...
Li FW, Luo SK
doaj
Systematic transcriptome wide analysis of lncRNA-miRNA interactions [PDF]
, 2012 Long noncoding RNAs (lncRNAs) are a recently discovered class of non-protein coding RNAs which have now increasingly been shown to be involved in a wide variety of biological processes as regulatory molecules. Little is known regarding the regulatory interactions between noncoding RNA classes.
arxiv +1 more source
Essential role of long non-coding RNAs in de novo chromatin modifications: The genomic address code hypothesis [PDF]
Biophysical Reviews Vol. 9, pp. 73-77 (2017), 2017 The epigenome, i.e. the whole of chromatin modifications, is transferred from mother to daughter cells during cell differentiation. When de novo chromatin modifications (establishment or erasure of, respectively, new or pre-existing DNA methylations and/or histone modifications) are made in a daughter cell, however, it has a different epigenome than ...
arxiv +1 more source
Learning of signaling networks: molecular mechanisms [PDF]
Trends in Biochemical Sciences (2020) 45, 284-294, 2020 Molecular processes of neuronal learning have been well-described. However, learning mechanisms of non-neuronal cells have not been fully understood at the molecular level. Here, we discuss molecular mechanisms of cellular learning, including conformational memory of intrinsically disordered proteins and prions, signaling cascades, protein ...
arxiv +1 more source
Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022 Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem +6 more
wiley +1 more source
Functions and properties of nuclear lncRNAs—from systematically mapping the interactomes of lncRNAs [PDF]
Journal of Biomedical Science, 2020 AbstractProtein and DNA have been considered as the major components of chromatin. But beyond that, an increasing number of studies show that RNA occupies a large amount of chromatin and acts as a regulator of nuclear architecture. A significant fraction of long non-coding RNAs (lncRNAs) prefers to stay in the nucleus and cooperate with protein ...
Hsueh-Ping Chu +2 more
openaire +4 more sources
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
International Journal of Nanomedicine, 2023 Chenyi Zhang,1,* Lai Pan,1,* Haizheng Zhang,1 Ting Ke,1 Yuxuan Yang,1 Lan Zhang,2 Lili Chen,1 Jingyi Tan1 1Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, People’s Republic of ...
Zhang C +7 more
doaj
Association Between lncRNA HULC rs7763881 Polymorphism and Gastric Cancer Risk
Pharmacogenomics and Personalized Medicine, 2020 Jang Hee Hong,1,2,* Eun-Heui Jin,3,* In Ae Chang,1 Hyojin Kang,1 Sang-Il Lee,4 Jae Kyu Sung5 1Clinical Trials Center, Chungnam National University Hospital, Daejeon, Republic of Korea; 2Department of Pharmacology, Chungnam National University College of ...
Hong JH +5 more
doaj