Results 181 to 190 of about 79,026 (218)

Big Data in Cancer Genomics: Computational Foundations and Emerging Pathways for Precision Oncology

open access: yesComputational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT This review aims to explore the computational foundations of big data in cancer genomics and examine emerging pathways that support precision oncology and personalized cancer care. A narrative review approach was adopted to synthesize evidence from PubMed, Scopus, Web of Science, and IEEE Xplore.
Nur Vanu   +8 more
wiley   +1 more source

Integrated Analysis of lncRNA–miRNA–mRNA ceRNA Network in Order to Discover Potential Novel Biomarkers in Stomach Cancer

open access: yesComputational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Stomach cancer (SC) or gastric cancer (GC) is one of the most common gastrointestinal malignancies. Currently, some studies based on competing endogenous RNAs (ceRNA) network analysis have been assessed for this cancer. The construction and analysis of ceRNA network is a novel approach for identification of RNA‐based biomarkers in cancer ...
Habib MotieGhader   +2 more
wiley   +1 more source

Bioinformatics Identification of lncRNA‐Associated Molecular Signatures Potentially Related to Quercetin Response in Breast Cancer

open access: yesComputational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Breast cancer affects approximately one in every eight women globally, as reported by the World Health Organization. Among all female malignant tumors, breast cancer has the highest fatality rate, surpassed only by lung cancer. Advanced stages of this disease are almost always fatal, and despite the advancements in surgical techniques and ...
Mahboobeh Mehrabani Natanzi   +2 more
wiley   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

open access: yesInternational Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari   +10 more
wiley   +1 more source

ELE: Estimating tissue‐specific long noncoding RNA gene essentiality using graph neural networks

open access: yesQuantitative Biology, Volume 14, Issue 4, December 2026.
Abstract A gene is essential if its loss of function results in lethality, reduced fitness, or disease. Essential genes have attracted increasing attention due to their vital functions in biological systems. Many efforts have been made to find essential protein‐coding genes.
Wan‐Ting Shi   +3 more
wiley   +1 more source

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