Results 191 to 200 of about 76,795 (267)

Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling

The FEBS Journal, EarlyView.
Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch, Gyula Ujlaki, Szilard Poliska, Nakayi Murahwa, Patrik Kovacs, Aladar Pettko‐Szandtner, Karen Uray, Peter Bai   +7 more
wiley   +1 more source

Genome-wide identification of long non-coding RNAs revealing their regulatory roles under seed development in ricebean (Vigna umbellata). [PDF]

BMC Plant Biol
Rattan P, Gandotra E, Mittal S.
europepmc   +1 more source

Distinctive gene expression in the reduced first thoracic legs of a nymphalid butterfly

Insect Molecular Biology, EarlyView.
Transcriptome analysis reveals that the small non‐walking front legs of a butterfly have distinct gene expression to the four walking legs. Reduced front legs express a gene with putative mechanosensory roles, a blue‐sensitive opsin and two homeobox genes.
Asia E. Hoile, Peter O. Mulhair, Peter W. H. Holland   +2 more
wiley   +1 more source

Identification and characterization of lncRNA-stemness-immune regulatory patterns. [PDF]

Brief Bioinform
Qian Z, Yin J, Zhang C, Wang G, Wang C, Li Y, Zhao Y.   +6 more
europepmc   +1 more source

The Emerging Role of UCHL1 in Neurological and Musculoskeletal Diseases

Immunology &Cell Biology, EarlyView.
UCHL1‐associated pathology. The pathological role of UCHL1 in multisystem diseases, including cancer, neurological, musculoskeletal and cardiovascular disorders. ABSTRACT Ubiquitin C‐terminal hydrolase L1 (UCHL1) is a highly conserved deubiquitinating enzyme that has transitioned from being viewed as a “brain‐specific” protein to a global regulator of ...
Ru Feng, Xiu Zhong, Jianjun Li, Adrian A. Achuthan   +3 more
wiley   +1 more source

Plasma lncRNA signature of upregulated ATP2B1-AS1 and downregulated RPL21P28 correlates with diagnosis and cognitive severity in Alzheimer's disease. [PDF]

Front Aging Neurosci
Yadollahi Khales A, Ghaedi K, Esmaeili F, Noorbakhshnia M, Etemadifar M.   +4 more
europepmc   +1 more source

Emerging Roles of PSTPIP2 in Autoimmunity: From Mechanism to Therapeutic Implications

Immunology, EarlyView.
PSTPIP2 acts as a key brake on myeloid inflammation by suppressing IL‐1β‐driven signalling, macrophage dysregulation and inflammation‐associated bone remodelling. Its emerging roles in CRMO/CMO, rheumatoid arthritis, SAPHO syndrome and bullous pemphigoid support its potential as a biomarker and therapeutic target.
Erdong Zhang, Fengyu Liu, Yongle Wei, Guoqiang Li, Liujie Zheng, Lin Jin, Feng Luan, Yingze Zhang, Ling Wang, Zhiyong Hou   +9 more
wiley   +1 more source

Cross-Level Regulatory Interactions Underlying Human Immune Aging. [PDF]

MedComm (2020)
Wu Q, Zhang B, Zhi X, Zhang Q, Zhang K, Wang Y, Zhang K, Feng L, Cheng S, Xiao T.   +9 more
europepmc   +1 more source

Noncoding RNAs as novel diagnostic biomarkers for diabetic retinopathy: A systematic review and meta‐analysis

Journal of Diabetes Investigation, EarlyView.
The systematic review and meta‐analysis (Embase, PubMed, and Web of Science; up to August 2025) evaluated circulating noncoding RNAs (ncRNAs) as noninvasive early diagnostic biomarkers for diabetic retinopathy (DR). From 17 articles (24 studies, 1,983 DR patients vs 1,437 controls), a random‐effects model yielded pooled sensitivity of 0.81, specificity
Ting Zhang, Donghong Xu
wiley   +1 more source

Weighted gene co-expression network analysis reveals key genes and lncRNAs in <i>Bos indicus</i> chronically infected with Johne's disease. [PDF]

Front Immunol
Sahu A, Abdullah M, Gupta S, Singh SV, Dhillon A, Yadav P, Azam S.   +6 more
europepmc   +1 more source