Results 11 to 20 of about 73,797 (157)
Cancers, 2021 Non-coding RNAs (ncRNAs) have been considered as unimportant additions to the transcriptome. Yet, in light of numerous studies, it has become clear that ncRNAs play important roles in development, health and disease. Long-ignored, long non-coding RNAs (lncRNAs), ncRNAs made of more than 200 nucleotides have gained attention due to their involvement as ...
Lidia Borkiewicz +4 more
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E2F1-induced lncRNA, EMSLR regulates lncRNA LncPRESS1 [PDF]
Scientific Reports, 2022 AbstractE2F1 induces hundreds of protein-coding genes influencing diverse signaling pathways but much less is known about its non-coding RNA targets. For identifying E2F1-dependent oncogenic long non-coding RNAs (lncRNAs), we carried out genome-wide transcriptome analysis and discovered an lncRNA, EMSLR, which is induced both in lung adenocarcinoma ...
Priyanka Priyanka +3 more
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Tumor immune microenvironment lncRNAs [PDF]
Briefings in Bioinformatics, 2021 AbstractLong non-coding ribonucleic acids (RNAs) (lncRNAs) are key players in tumorigenesis and immune responses. The nature of their cell type-specific gene expression and other functional evidence support the idea that lncRNAs have distinct cellular functions in the tumor immune microenvironment (TIME).
Eun-Gyeong Park +4 more
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Revealing protein–lncRNA interaction [PDF]
Briefings in Bioinformatics, 2015 Long non-coding RNAs (lncRNAs) are associated to a plethora of cellular functions, most of which require the interaction with one or more RNA-binding proteins (RBPs); similarly, RBPs are often able to bind a large number of different RNAs. The currently available knowledge is already drawing an intricate network of interactions, whose deregulation is ...
FERRE', FABRIZIO +2 more
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The LncRNA Connectivity Map: Using LncRNA Signatures to Connect Small Molecules, LncRNAs, and Diseases [PDF]
Scientific Reports, 2017 AbstractWell characterized the connections among diseases, long non-coding RNAs (lncRNAs) and drugs are important for elucidating the key roles of lncRNAs in biological mechanisms in various biological states. In this study, we constructed a database called LNCmap (LncRNA Connectivity Map), available at http://www.bio-bigdata.com/LNCmap/, to establish ...
Haixiu Yang +11 more
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Function of lncRNAs and approaches to lncRNA-protein interactions [PDF]
Science China Life Sciences, 2013 Long non-coding RNAs (lncRNAs), which represent a new frontier in molecular biology, play important roles in regulating gene expression at epigenetic, transcriptional and post-transcriptional levels. More and more lncRNAs have been found to play important roles in normal cell physiological activities, and participate in the development of varieties of ...
Zhu, JuanJuan +3 more
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LncRNA POU3F3 promotes melanoma cell proliferation by downregulating lncRNA MEG3 [PDF]
Discover Oncology, 2021 Abstract Background LncRNA POU3F3 (POU3F3) is overexpressed and plays oncogenic roles in esophageal squamous-cell carcinomas. LncRNA MEG3 (MEG3) has been characterized as a tumor suppressive lncRNA in different types of cancer.
Liu, Yingnan +3 more
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Oncology Letters, 2016 Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs composed of >200 nucleotides. Recent studies have revealed that lncRNAs exert an important role in the development and progression of cancer. In this review, the involvement of the most extensively investigated lncRNAs in cancers of the digestive, respiratory, reproductive, urinary and ...
Rui, Zhang +4 more
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Involvement of long non-coding RNAs in glioblastoma and research approaches and techniques to study lncRNAs in tumors: a review [PDF]
World Cancer Research JournalGlioblastoma is recognized as the most aggressive tumor of the central nervous system, accounting for the majority of gliomas (57.3%) and approximately 15% of all brain tumors.
O. Bouchra +4 more
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Open Medicine, 2023 This study aimed to explore the prognostic and predictive value of autophagy-related lncRNAs in papillary thyroid carcinoma (PTC). The expression data of autophagy-related genes and lncRNAs of the PTC patients were obtained from TCGA database.
Hao Jie +5 more
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