Results 221 to 230 of about 31,278 (264)
Expression Landscape and Circadian Regulation of lncRNAs in the Kidney
Acta Physiologica, Volume 242, Issue 8, August 2026.ABSTRACT Recent multi‐omics work shows that the diurnal rhythmicity of kidney function is associated with circadian oscillations in renal mRNA, protein and metabolite abundances. Yet circadian regulation of renal lncRNAs, which are emerging as important modulators of diverse (patho)physiological processes, remains largely unexplored. Here, we provide a
Leonore Wigger +4 more
wiley +1 more source
International Journal of Cancer, Volume 159, Issue 2, Page 302-319, 15 July 2026.Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon +5 more
wiley +1 more source
A Myocyte‐Enriched Long Non‐Coding RNA NRMLncR Enhances Myogenesis in Mouse
The FASEB Journal, Volume 40, Issue 13, 15 July 2026.We identified a novel myocyte‐enriched, Notch‐repressed myogenic lncRNA, NRMLncR, that is induced by myogenic regulatory factors (MRFs) during myogenic progression in mouse. NRMLncR localizes to cytoplasmic and nuclear compartments, associates with the RNA‐binding protein CUGBP Elav‐like family member 1 (CELF1), and is linked to neighboring gene Tbx1 ...
Yufen Li +12 more
wiley +1 more source
Advanced Science, Volume 13, Issue 37, 3 July 2026.Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng +14 more
wiley +1 more source
TRIAGE Toolkit: Streamlined Discovery of Regulatory Genes and Elements
Current Protocols, Volume 6, Issue 7, July 2026.Abstract Efficient discovery of regulatory genes and elements is essential for understanding cell identity, differentiation, and disease mechanisms. The TRIAGE methods are a set of well‐established computational approaches that identify context‐specific regulatory genes and prioritize regulatory elements across the genome.
Qiongyi Zhao +6 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.NFIC/METTL3 negative feedback loop in NSCLC cells suppresses exosomal miR‐194‐5p via m6A methylation; reduced miR‐194‐5p deepresses ZNF106 in macrophages, promoting M2 polarization and IL‐6 secretion; Macrophage‐derived IL‐6 activates JAK2/STAT3 in NSCLC cells to upregulate METTL3, forming a positive feedback loop.
Shu Fang +12 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 4, July 2026.ABSTRACT Oleic acid (C18:1), a monounsaturated fatty acid, is a key determinant of nutritional value and oxidative stability of vegetable oils. Increasing its concentration has therefore become a central objective in oilseed crop improvement. This review summarizes current knowledge on the molecular mechanisms and breeding strategies underlying oleic ...
Muhammad Jawad Umer +12 more
wiley +1 more source
PKMYT1 in Cancer: Beyond Cell Cycle Checkpoints to Context‐Dependent Therapeutic Vulnerability
Genes, Chromosomes and Cancer, Volume 65, Issue 7, July 2026.ABSTRACT PKMYT1 has emerged as a promising therapeutic target distinguished by its tumor‐selective expression and essential role in replication stress management. Unlike WEE1, PKMYT1 is dispensable in normal cell cycles but critical for cancer cells coping with DNA damage, establishing a broad therapeutic window.
Lingxi Li +5 more
wiley +1 more source
Multiple myeloma: A tale of deregulated transcription factors
HemaSphere, Volume 10, Issue 7, July 2026.Abstract A comprehensive understanding of the molecular mechanisms underlying multiple myeloma (MM) pathogenesis is essential for developing therapeutic strategies that overcome disease heterogeneity and treatment relapse. In this review, we focus on transcription factors (TFs), key regulators of gene expression that play critical roles in normal ...
Nahia Gómez‐Echarte +5 more
wiley +1 more source
LncRNA Mirt2 Attenuates Osteoarthritis Progression by Promoting miR‐429/TBK1‐Mediated Autophagy
Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.LncRNA Mirt2 promoted chondrocyte proliferation and alleviated chondrocyte apoptosis, inflammation, and cartilage degeneration by activating miR‐429/TBK1‐mediated autophagy. Consequently, lncRNA Mirt2 has the potential to be used in the future clinical diagnosis and treatment of OA.
Jian‐xin Zhang +6 more
wiley +1 more source