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The role of lncRNAs and exosomal lncRNAs in cancer metastasis
Biomedicine and Pharmacotherapy, 2023 Tumor metastasis is the main reason for cancer-related death, but there is still a lack of effective therapeutic to inhibit tumor metastasis. Therefore, the discovery and study of new tumor metastasis regulators is a prominent measure for cancer diagnosis and treatment. Long non-coding RNA (lncRNA) is a type of non-coding RNAs over 200 bp in length. It
Xiaojie Si, Honglin Dai
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Clinica Chimica Acta, 2022
Osteoarthritis (OA) is a progressive joint disease that affects millions of older adults around the world. With increasing rates of incidence and prevalence worldwide, OA has become an enormous global socioeconomic burden on healthcare systems. Long non-coding ribonucleic acids (lncRNAs), essential functional molecules in many biological processes, are
Okuyan, Hamza Malik, Begen, Mehmet A.
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Osteoarthritis (OA) is a progressive joint disease that affects millions of older adults around the world. With increasing rates of incidence and prevalence worldwide, OA has become an enormous global socioeconomic burden on healthcare systems. Long non-coding ribonucleic acids (lncRNAs), essential functional molecules in many biological processes, are
Okuyan, Hamza Malik, Begen, Mehmet A.
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Clinica Chimica Acta, 2015
Long noncoding RNAs are emerging as new mediators of tumorigenesis by virtue of their various functions and their capacity to induce different mechanisms as a result of their wide spectrum of interactions. They play critical roles in a broad range of cellular processes including regulation of gene expression, imprinting, chromatin modification ...
Mustafa, Isin, Nejat, Dalay
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Long noncoding RNAs are emerging as new mediators of tumorigenesis by virtue of their various functions and their capacity to induce different mechanisms as a result of their wide spectrum of interactions. They play critical roles in a broad range of cellular processes including regulation of gene expression, imprinting, chromatin modification ...
Mustafa, Isin, Nejat, Dalay
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International Immunopharmacology, 2018
Long noncoding RNAs (lncRNAs) are emerging as crucial regulators of gene expression in immune system. It has been reported that lncRNAs participate in regulation of immune responses through both transcriptional and post-transcriptional mechanisms. In this review, we summarize the molecular functions of lncRNAs and discuss their binding to DNA, RNA and ...
Xue Li, Nan Li
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Long noncoding RNAs (lncRNAs) are emerging as crucial regulators of gene expression in immune system. It has been reported that lncRNAs participate in regulation of immune responses through both transcriptional and post-transcriptional mechanisms. In this review, we summarize the molecular functions of lncRNAs and discuss their binding to DNA, RNA and ...
Xue Li, Nan Li
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lncRNAs in mesenchymal differentiation
American Journal of Physiology-Cell Physiology, 2022In recent years, technological advances have revealed a large potential number of long noncoding RNAs (lncRNAs). Findings recognize lncRNAs as orchestrating molecules in a wide range of processes, at the transcriptional and posttranscriptional levels, although fewer studies address function. For differentiation, which consists of rearrangements in the
Marcela Angelica, De la Fuente-Hernandez +3 more
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Clinica Chimica Acta, 2019
Ovarian cancer is one of the most common gynecologic malignancies and has a poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators of cancer development. Studies have shown that the dysregulation of lncRNAs is frequently observed in ovarian cancer and greatly contributes to malignant phenotypical changes. In this
Lijuan Chen
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Ovarian cancer is one of the most common gynecologic malignancies and has a poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators of cancer development. Studies have shown that the dysregulation of lncRNAs is frequently observed in ovarian cancer and greatly contributes to malignant phenotypical changes. In this
Lijuan Chen
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LncRNA NKILA Inhibits Retinoblastoma by Downregulating lncRNA XIST
Current Eye Research, 2019Purpose: Although retinoblastoma is rare but can be deadly in some severe cases. To find novel therapeutic targets for retinoblastoma, we explored the potential role of lncRNA NKILA in retinoblastoma. Results: We found that, comparing to healthy controls, NKILA was downregulated, while lncRNA XIST was upregulated in plasma of retinoblastoma patients ...
Xueman, Lyu +4 more
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CircRNAs and LncRNAs in Osteoporosis
Differentiation, 2020Osteoporosis is a systemic bone disease with bone fragility and increased fracture risk. The non-coding RNAs (ncRNAs) have appeared as important regulators of cellular signaling and pertinent human diseases. Studies have demonstrated that circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) are involved in the progression of osteoporosis through
Tiantian He +9 more
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2021
Although the great majority of cancers share a defined group of hallmarks that is responsible for the uncontrolled growth of particular cell types, it is today clear that under the name of cancer we refer to hundreds of different diseases. Furthermore, each of these diseases has an intrinsic variability due to the genetic background in which it ...
Iaccarino, Ingram, Klapper, Wolfram
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Although the great majority of cancers share a defined group of hallmarks that is responsible for the uncontrolled growth of particular cell types, it is today clear that under the name of cancer we refer to hundreds of different diseases. Furthermore, each of these diseases has an intrinsic variability due to the genetic background in which it ...
Iaccarino, Ingram, Klapper, Wolfram
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The functions of LncRNA in the heart
Diabetes Research and Clinical Practice, 2020Cardiovascular disease is a major cause of death and disability worldwide. Recently, increasing evidence has demonstrated that various lncRNAs play critical roles in the pathogenesis of cardiovascular diseases, including myocardial ischemia and reperfusion (I/R) injury. LncRNAs are transcripts longer than 200 nucleotides. They are considered a class of
Yao, Wang, Xianglan, Sun
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