Results 91 to 100 of about 1,672,319 (284)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

On the Kernel properties of the integral equation for the model with the essentially loaded heat equation

Eurasian Physical Technical Journal, 2019
Mathematical modeling of thermophysical processes in an electric arc of high-current disconnecting apparatuses leads to a boundary value problem for an essentially loaded heat conduction equation. Taking into account the transience of such phenomena, in
A.N. Yesbayev, G.A. Yessenbayeva, G.A. Yessenbayeva, M.I. Ramazanov   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

BVP for the heat equation with a fractional integro-differentiation operator

Қарағанды университетінің хабаршысы. Математика сериясы
A boundary value problem for a loaded heat conduction equation is considered, when the loaded term has the form of a fractional Riemann-Liouville derivative with respect to a spatial variable, and the loading point moves with a variable velocity.
M.T. Kosmakova, N.T. Orumbayeva, D.M. Akhmanova, L.Zh. Kasymova   +3 more
doaj   +1 more source

Correlations between Axial and Oblique Loaded Column

MATEC Web of Conferences, 2017
In an impact, a structure is rarely subjected to pure axially loading. Load endured by an axially loaded column has been analytically derived by previous researchers, whereas it is very limited works on predicting the obliquely loaded column performance.
Salleh Salwani Mohd, Sahari Barkawi, Ali Aidy, Hassan Mas Ayu, Daud Rosdi   +4 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Explicit Solution of the Time Domain Volume Integral Equation Using a Stable Predictor-Corrector Scheme [PDF]

, 2012
An explicit marching-on-in-time (MOT) scheme for solving the time domain volume integral equation is presented. The proposed method achieves its stability by employing, at each time step, a corrector scheme, which updates/corrects fields computed by the ...
Bağcı, H, Benson, Trevor, Sewell, P, Vukovic, A, Al Jarro, Ahmed, Bagci, Hakan, Al-Jarro, A, Benson, TM, Salem, MA, Salem, Mohamed, Sewell, Phillip D., Vuković, Ana   +11 more
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Numerical Determination of a Time-Dependent Source in a Modified Benjamin–Bona–Mahony Equation

Mathematics
In this paper, we consider a modified Benjamin–Bona–Mahony (BBM) equation, which, for example, arises in shallow-water models. We discuss the well-posedness of the Dirichlet initial-boundary-value problem for the BBM equation. Our focus is on identifying
Miglena N. Koleva, Lubin G. Vulkov
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source