Results 81 to 90 of about 1,672,319 (284)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Singularities in mass-loaded MHD flow: The cometary bow shock [PDF]

, 1991
We present a one-dimensional model of the mass-loading of the solar wind by cometary ions which predicts a singularity in the mass-loaded flow at M = 2. Further, a subshock occurs when the flow speed reaches M almost-equal-to 1.15.
A. J. Coates, Coates, AJ, Khabibrakhmanov, IK, I. Kh. Khabibrakhmanov, V. L. Galinsky, Galinsky, VL   +5 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Difference methods for solving some classes of multidimensional loaded parabolic equations with boundary conditions of the first kind

Известия высших учебных заведений. Поволжский регион: Физико-математические науки
Background. In the literature, loaded differential equations are usually called equations containing functions of the solution on manifolds of smaller dimension than the dimension of the domain of definition of the sought function.
Zaryana V. Beshtokova, Valentina A. Vodakhova, Marat Z. Khudalov   +2 more
doaj   +1 more source

Pyraclostrobin-loaded poly (lactic-co-glycolic acid) nanospheres: Preparation and characteristics

Journal of Integrative Agriculture, 2018
We used poly (lactic-co-glycolic acid) (PLGA) as a carrier polymer for pyraclostrobin-loaded nanospheres. Using the ultrasound emulsification-solvent evaporation method, the physicochemical characteristics and release properties of the pyraclostrobin ...
Ming-ming YIN, Yu ZHENG, Fu-liang CHEN
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

APPROXIMATION OF THE HOPF EQUATION BY LOADED EQUATIONS

Bulletin of the Moscow State Regional University (Physics and Mathematics), 2020
Oleg L. Boziev, Mukhamed A. Abazokov
openaire   +2 more sources

METHOD OF LINES FOR A LOADED PARABOLIC EQUATION

Journal of Mathematics Mechanics and Computer Science
In a closed domain, a two-point boundary value problem for loaded parabolic equations is considered. The method of lines with respect to the variable x is used to solve this problem. As a result of this approach, a discretized problem is formulated.
Saule Kuanysh, Anar Assanova, Zhazira Kadirbayeva   +2 more
openaire   +1 more source

Investigation of the model for the essentially loaded heat equation

Eurasian Physical Technical Journal, 2019
The studied problem for the essentially loaded heat equation is connected with mathematical modeling of thermophysical processes in the electric arc of high-current disconnecting devices. Experimental studies of such phenomena are difficult due to their
A.N. Yesbayev, G.A. Yessenbayeva, M.I. Ramazanov   +2 more
doaj   +1 more source