Results 101 to 110 of about 1,672,319 (284)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Spectral solution of load flow equations

, 2018
The load-flow equations are the main tool to operate and plan electrical networks. For transmission or distribution networks these equations can be simplified into a linear system involving the graph Laplacian and the power input vector. We show, using spectral graph theory, how to solve this system efficiently.
Caputo, J. G., Knippel, A., Retiere, N.
openaire   +2 more sources

Non-local problems with integral gluing condition for loaded mixed type equations involving the Caputo fractional derivative

Electronic Journal of Differential Equations, 2016
In this work, we study the existence and uniqueness of solutions to non-local boundary value problems with integral gluing condition. Mixed type equations (parabolic-hyperbolic) involving the Caputo fractional derivative have loaded parts in Riemann ...
Obidjon Kh. Abdullaev, Kishin S. Sadarangani   +1 more
doaj  

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

A generalized - expansion method for the loaded negative order Korteveg-de Vries equation: A generalized - expansion method for the loaded negative order Korteveg-de Vries equation

Keywords : solution, loaded modified negative order Korteveg-de Vries equation, nonlinear equations, expansion methodThis paper is dedicated to find the solutions of the equation of the loaded negative order Korteveg de Vries equation.
Уразбоев, У.У, Исмоилов, О.Б., Хасанов, М. М.   +2 more
core   +1 more source

Numerical-analytical method for solving initial-boundary value problem for loaded parabolic equation

Қарағанды университетінің хабаршысы. Математика сериясы
An initial-boundary value problem for a loaded parabolic equation in a rectangular domain was considered. By discretization with respect to a spatial variable, the problem under study is reduced to the initial problem for a system of loaded ordinary ...
A.T. Assanova, Zh.M. Kadirbayeva, S.K. Kuanysh   +2 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source