Results 61 to 70 of about 605,433 (293)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Boundary value problems for essentially-loaded parabolic equation

Қарағанды университетінің хабаршысы. Математика сериясы, 2018
In this paper we investigate the first boundary value problem for essentially loaded equation of heat conduction, i.e. when laden terms are derivatives for any finite order.
M.I. Ramazanov, M.T. Kosmakova, V.G. Romanovsky, B.H. Zhanbusinova, Zh.M Tuleutaeva   +4 more
doaj   +1 more source

Shaping an ultracold atomic soliton in a travelling wave laser beam

, 1997
An ultracold wave packet of bosonic atoms loaded into a travelling laser wave may form a many-atom soliton.This is disturbed by a homogeneous force field, for example by the inevitable gravitation.
Anderson M. H. ., J Audretsch, Kodama Y., M Holzmann, Wright E. M.   +4 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

To the Solution of Loaded Differential Equations with Nonlocal Conditions

Известия Иркутского государственного университета: Серия "Математика"
We investigate a system of linear ordinary differential equations containing point and integral loadings with nonlocal boundary conditions. Boundary conditions include integral and point values of the unknown function. An essential feature of the problem
V.M. Abdullaev
doaj   +1 more source

Deflection of a Viscoelastic Cantilever under a Uniform Surface Stress: Applications to Static-mode Microcantilever Sensors Undergoing Adsorption [PDF]

, 2009
The equation governing the curvature of a viscoelastic microcantilever beam loaded with a uniform surface stress is derived. The present model is applicable to static-mode microcantilever sensors made with a rigid polymer, such as SU-8.
Heinrich, Stephen M., Josse, Fabien, Wenzel, Michael J.   +2 more
core   +1 more source

Continuous optical loading of a Bose-Einstein Condensate in the Thomas-Fermi regime

, 2003
We discuss the optical loading of a Bose-Einstein condensate in the Thomas-Fermi regime. The condensate is loaded via spontaneous emission from a reservoir of excited-state atoms.
Cirac J. I., F Floegel, Floegel F., Gardiner C., Inguscio M., Janicke U., L Santos, M Lewenstein, Meystre P., Olshan'ii M., Roos C. F., Spreeuw R. J. C.   +11 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source