Results 61 to 70 of about 1,672,319 (284)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

О единственности и непрерывной зависимости от входных данных решения системы двух нагруженных параболических уравнений с данными Коши

, 2019
We study the Cauchy problem for the system of one-dimensional loaded parabolic equations. Uniqueness and continuous dependence of solutions on the initial data in the class of smooth bounded functions is provedМы рассматриваем задачу Коши для системы ...
Terskikh, Natalya M., Фроленков, Игорь В., Терских, Наталья М., Antipina, Irina S., Антипина, Ирина С., Frolenkov, Igor V.   +5 more
core   +1 more source

Numerical Solution of Locally Loaded Volterra Integral Equations

Computation
Loaded Volterra integral equations represent a novel class of integral equations that have attracted considerable attention in recent years due to their numerous applications in various fields of science and engineering. This class of Volterra integral equations is characterized by the presence of a loading function, which complicates their theoretical
Vladislav Byankin, Aleksandr Tynda, Denis N. Sidorov, Aliona Dreglea   +3 more
openaire   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Load Balancing for the Numerical Solution of the Navier-Stokes Equations

, 2007
In this paper, we simulate the performance of a load balancing scheme. In particular, we study the application of the Extrapolated Diffusion(EDF) method for the efficient parallelization of a simple atmospheric model. It involves the numerical solution of the steady state Navier-Stokes(NS) equations in the horizontal plane and random load values ...
Gregory Karagiorgos, Petros Katsafados, Andreas Kontarinis, Nikolaos M. Missirlis, Filippos Tzaferis   +4 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Source Identification for a Two-Dimensional Parabolic Equation with an Integral Constraint

Mathematics
We consider a two-dimensional parabolic problem subject to both Neumann and Dirichlet boundary conditions, along with an integral constraint. Based on the integral observation, we solve the inverse problem of a recovering time-dependent right-hand side ...
Miglena N. Koleva, Lubin G. Vulkov
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Finite-difference method for solving the first boundary value problem for a non-stationary loaded moisture transfer equation

Известия высших учебных заведений. Поволжский регион: Физико-математические науки
Background. One of the important sections of the theory of differential equations is loaded equations. They allow us to model processes in which the influence of external factors significantly changes the behavior of the system.
M.Kh. Beshtokov
doaj   +1 more source