Results 71 to 80 of about 1,672,319 (284)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
STRESS CONCENTRATION FACTOR ON ORTHOTROPIC PLATE WITH PIN-LOADED HOLE
, 2013 : The presence of hole in aerospace structures usually cannot be avoided. The hole produces a serious problem, since this will trigger a surge in the stress in the adjacent of the hole that may lead to the failure of the structures.
Arya Prihutama Sumarjanto +1 more
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 2018 Gravity shapes us. From birth to death, what bodies can do is bound by what they weigh. Things fall, softly or heavily, constantly or all at once. Some things are too heavy to carry, or to lift. Some things carry us.
Rushe, Sinéad
core +2 more sources
On the solvability of the Goursat problem for one class of loaded second-order hyperbolic equations
Қарағанды университетінің хабаршысы. Математика сериясыIn this paper the solvability of the Goursat problems for two locally loaded second-order hyperbolic equations with a wave operator in the main part was explored.
A.Kh. Attaev
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Cutout reinforcements for shear loaded laminate and sandwich composite panels [PDF]
, 2008 This paper presents the numerical and experimental studies of shear loaded laminated and sandwich carbon/epoxy composite panels with cutouts and reinforcements aiming at reducing the cutout stress concentration and increasing the buckling stability of
Guo, Shijun J., Zhou, L., Cheung, C. W.
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source