Results 111 to 120 of about 1,104,255 (313)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Linking collective action to non-timber forest product market for improved local livelihoods: Challenges and opportunities [PDF]

open access: yes
"The paper draws on findings from research in South Sulawesi and Jambi Provinces, Indonesia, looking at the role of collective action in helping two local community groups enhance their bargaining power vis a vis other market players (such as collectors,
Komarudin, Heru   +2 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Impact of Local Structures on Socio-Political Action;Case: Baluch in Iran

open access: yesتحقيقات جغرافيايی, 2018
Introduction and Background There is a relationship between local structures and individual and social actions. These relationships are formed before they are determined. These structures are not entirely objective frameworks.
barzin Zarqami, Ebrahim Roumina
doaj  

Alike in diversity? Local action groups in nine European countries

open access: yes, 2022
Local Action Groups (LAGs) are seen as an integral part in the development of rural economies across the EU. They are a strong network of interaction between the local state and society.
Teles, Filipeeditor   +9 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Structure-Preserving Binary Representations for RGB-D Action Recognition

open access: yes, 2015
In this paper, we propose a novel binary local representation for RGB-D video data fusion with a structure-preserving projection. Our contribution consists of two aspects.
Liu, Li, Shao, Ling, Yu, Mengyang
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

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