Results 111 to 120 of about 6,762,995 (257)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Preferential allosteric modulation of Otop1 channels by small molecule compounds

Communications Biology
The Otopetrin (Otop) proteins, comprising Otop1-3, are proton-gated proton channels with key biological functions. Otop1 acts as a receptor for sour and ammonium salt tastes in mammals, but its gating mechanisms and pharmacology remain poorly understood.
Xiangjin Kong, Jie Sun, Hanhan Zhang, Yuan Yin, Xinyao Liang, Yan Chen, Guoqing Luo, Huixin Xia, Youjun Wang, Zhonghua Liu, Cheng Tang   +10 more
doaj   +1 more source

Deformation Control for Foundation Pit Segmented Construction Adjacent to Operational High-speed Railway Lines

Chengshi guidao jiaotong yanjiu
Objective Limited land use resource and arrangement adjacent to operational high-speed railway lines pose significant challenges to some city foundation pit constructions and the railway operational safety.
LI Xiaolong, LIAO Weilian, XIAO Fei, CHEN He, DI Honggui, HE Shuqi   +5 more
doaj   +1 more source

ANALISIS PENGUKURAN KINERJA KEUANGAN PEMERINTAH DAERAH TAPAL KUDA DI JAWA TIMUR DITINJAU DARI SEGI EFISIENSI DAN EFEKTIFITAS [PDF]

, 2007
This research is a case study on horseshoe Local Government in East Java under the title "Analysis of Financial Performance Measurement In Local Government horseshoe East Java Based View of Efficiency and Effectiveness" Peneliltian aim is to describe and
Liliyana, Liliyana
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Classification of Coastal Benthic Substrates Using Supervised and Unsupervised Machine Learning Models on North Shore of the St. Lawrence Maritime Estuary (Canada)

Geomatics
Classification of benthic substrates is a core necessity in many scientific fields like biology, ecology, or geology, with applications branching out to a variety of industries, from fisheries to oil and gas.
Guillaume Labbé-Morissette, Théau Leclercq, Patrick Charron-Morneau, Dominic Gonthier, Dany Doiron, Mohamed-Ali Chouaer, Dominic Ndeh Munang   +6 more
doaj   +1 more source

The development and year one implementation of the Local Justice Reinvestment Pilot [PDF]

, 2013
This report focuses on the initial findings from a process evaluation of the Local Justice Reinvestment pilot (commissioned by the Ministry of Justice), which examines the early development and implementation of the pilot in the first test year.
Barraclough, Nicola, Meadows, Linda, Warburton, Frank, Webb, Sarah, Wong, Kevin, Young, Helen   +5 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

EVALUATING THE EFFICIENCY OF LOCAL ECONOMIC DEVELOPMENT POLICIES [PDF]

This paper studies the way public authorities can fundament and evaluate the local economic development policies they want to promote, according to their efficiency.
Sarac Ionut Pavel, Sautiut Lavinia Sidonia   +1 more
core