Results 61 to 70 of about 247,781 (292)

Existence of Solutions for Coupled Higher-Order Fractional Integro-Differential Equations with Nonlocal Integral and Multi-Point Boundary Conditions Depending on Lower-Order Fractional Derivatives and Integrals

Mathematics, 2022
In this article, we investigate the existence and uniqueness of solutions for a nonlinear coupled system of Liouville–Caputo type fractional integro-differential equations supplemented with non-local discrete and integral boundary conditions.
Muthaiah Subramanian, Jehad Alzabut, Mohamed I. Abbas, Chatthai Thaiprayoon, Weerawat Sudsutad   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Variational Iteration Transform Method for Fractional Differential Equations with Local Fractional Derivative

Abstract and Applied Analysis, 2014
We propose the variational iteration transform method in the sense of local fractional derivative, which is derived from the coupling method of local fractional variational iteration method and differential transform method.
Yong-Ju Yang, Liu-Qing Hua
doaj   +1 more source

Traveling waves for a bistable equation with nonlocal-diffusion [PDF]

, 2013
We consider a single component reaction-diffusion equation in one dimension with bistable nonlinearity and a nonlocal space-fractional diffusion operator of Riesz-Feller type.
Achleitner, Franz, Kuehn, Christian
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Certain Hadamard Proportional Fractional Integral Inequalities

Mathematics, 2020
In this present paper we study the non-local Hadmard proportional integrals recently proposed by Rahman et al. (Advances in Difference Equations, (2019) 2019:454) which containing exponential functions in their kernels.
Gauhar Rahman, Kottakkaran Sooppy Nisar, Thabet Abdeljawad   +2 more
doaj   +1 more source

A mechanical approach to fractional non-local thermoelasticity [PDF]

, 2010
In recent years fractional di erential calculus applications have been developed in physics, chemistry as well as in engineering elds. Fractional order integrals and derivatives ex- tend the well-known de nitions of integer-order primitives and ...
BORINO, Guido, DI PAOLA, Mario, ZINGALES, Massimiliano   +2 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source