Results 61 to 70 of about 7,145,429 (257)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Optimal control of fractional systems: a diffusive formulation [PDF]

, 2010
Optimal control of fractional linear systems on a finite horizon can be classically formulated using the adjoint system. But the adjoint of a causal fractional integral or derivative operator happens to be an anti-causal operator: hence, the adjoint ...
Matignon, Denis
core  

A Caputo-Type Fractional Derivative of a Function with Respect to Power Functions and Solutions to Non-Local Problems of Fractional Differential Equations

Mathematics
This paper investigates the uniform continuity and strong continuity of the semigroups of the fractional integral operators of power functions. Using the Krasnoselskii’s fixed-point theorem, we have studied the non-local problem related to fractional ...
Zhengzhi Lu
doaj   +1 more source

Stein-Weiss inequality for local mixed radial-angular Morrey spaces

Open Mathematics, 2022
In this article, a generalization of the well-known Stein-Weiss inequality for the fractional integral operator on functions with different integrability properties in the radial and the angular direction in local Morrey spaces is established.
Wei Mingquan, Su Fangming, Sun Lanyin
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

New inequalities using multiple Erdélyi–Kober fractional integral operators [PDF]

The role of fractional integral inequalities is vital in fractional calculus to develop new models and techniques in the most trending sciences. Taking motivation from this fact, we use multiple Erdélyi–Kober (M-E-K) fractional integral operators to ...
Md Kasmani, Ruhaila, Qureshi, Sania, Srivastava, Rekha, Alharbi, Rabab, Tassaddiq, Asifa, Kasmani, Ruhaila Md, Asifa Tassaddiq, Rekha Srivastava, Sania Qureshi, Rabab Alharbi, Ruhaila Md Kasmani   +10 more
core   +1 more source

Exact solutions of fractional mBBM equation and coupled system of fractional Boussinesq-Burgers

Results in Physics, 2018
The new exact solutions of nonlinear fractional partial differential equations (FPDEs) are established by adopting first integral method (FIM). The Riemann-Liouville (R-L) derivative and the local conformable derivative definitions are used to deal with ...
Shumaila Javeed, Summaya Saif, Asif Waheed, Dumitru Baleanu   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Fuzzy fractional integral equations under compactness type condition

, 2012
In this paper we study a fuzzy fractional integral equation. The fractional derivative is considered in the sense of Riemann-Liouville and we establish existence of the solutions of fuzzy fractional integral equations using the Hausdorff measure of ...
Arshad, Sadia, Agarwal, Ravi, O’Regan, Donal, Lupulescu, Vasile   +3 more
core   +1 more source

Spectral approximations to the fractional integral and derivative [PDF]

, 2012
In this paper, the spectral approximations are used to compute the fractional integral and the Caputo derivative. The effective recursive formulae based on the Legendre, Chebyshev and Jacobi polynomials are developed to approximate the fractional ...
Li, Changpin, Liu, Fawang, Fanhai Zeng, Changpin Li, Zeng, Fanhai, Fawang Liu   +5 more
core   +2 more sources