Results 111 to 120 of about 11,319,078 (248)

Vesicular Rps6 Released by Astrocytes in an Experimental Model of AD Regulates Local Translation and Enhances Synaptic Integrity in Neurones

Journal of Extracellular Vesicles
In neurones, like in any other cell, their function often relies on the fine‐tuning of their protein levels, which is achieved by the balance between protein synthesis and turnover.
María Gamarra, Aida de la Cruz‐Gambra, Maite Blanco‐Urrejola, Esperanza González, Mikel Azkargorta, Felix Elortza, Juan Manuel Falcón‐Pérez, Jimena Baleriola   +7 more
doaj   +1 more source

The autonomous axon: a model based on local synthesis of proteins

Biological Research, 2001
In the current understanding of axons, axoplasmic synthesis of proteins is negated, and it is asserted that proteins are transported from perikarya to axons. This 'transport model' in which axons are fully dependent of perikarya is seriously flawed.
openaire   +4 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis

Nature Communications
Motoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular connections.
Abdolhossein Zare, Saeede Salehi, Jakob Bader, Cornelius Schneider, Utz Fischer, Alexander Veh, Panagiota Arampatzi, Matthias Mann, Michael Briese, Michael Sendtner   +9 more
doaj   +1 more source

Active presynaptic ribosomes in the mammalian brain, and altered transmitter release after protein synthesis inhibition

eLife, 2018
Presynaptic neuronal activity requires the localization of thousands of proteins that are typically synthesized in the soma and transported to nerve terminals.
Matthew S Scarnati, Rahul Kataria, Mohana Biswas, Kenneth G Paradiso   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Mechanisms of pain processing: spinal protein translation in the rat [PDF]

, 2009
The word ‘pain’ is described by the International Association for the Study of Pain (IASP) as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.
Asante, C O, Asante, C.O.
core  

Oxygen-tolerant, Eosin Y mediated synthesis of protein-polymer biohybrids and protein-coated polymer nanoparticles [PDF]

To avoid the use of metal catalysts used in conventional approaches, an Eosin Y/TEMED mediated, photoinduced polymerization of vinyl monomers was optimized for the synthesis of protein-polymer conjugates.
Errika , Voutyritsa, Thomai, Lazou, Myrto, Charitaki, Stavroula, Margaritaki, Nikos , Hatzakis, Sune M. , Christensen, Jonida, Bushi, Kelly, Velonia   +7 more
core   +2 more sources

Lipid-mediated Protein-protein Interactions Modulate Respiration-driven ATP Synthesis [PDF]

, 2016
Energy conversion in biological systems is underpinned by membrane-bound proton transporters that generate and maintain a proton electrochemical gradient across the membrane which used, e.g. for generation of ATP by the ATP synthase.
von Ballmoos, Christoph, Brzezinski, Peter, Ädelroth, Pia, Nilsson, Tobias,, Rydström Lundin, Camilla,, Nilsson, Tobias, Lundin, Camilla Rydström, Nordlund, Gustav, Nordlund, Gustav,, von Ballmoos, Christoph,, Ädelroth, Pia,, Brzezinski, Peter,   +11 more
core   +2 more sources

Cloning of cDNA Encoding GRA1 Protein of Tachyzoite Toxoplasma Gondii Local Isolate

Indonesian Journal of Biotechnology, 2005
Gene encoding GRA1 protein is potent DNA-vaccine candidate against toxoplasmosis. The aim of the research was to clone the gene encoding GRA1 protein of tachyzoite Toxoplasma gondii local isolate by DNA recombinant technology.
Erma Sulistyaningsih, Sukarti Moeljopawiro, Jarot Subandono, Wayan T. Artama   +3 more
doaj   +1 more source