Results 121 to 130 of about 909,585 (312)

Corrigendum: Object-Based Analyses in FIJI/ImageJ to Measure Local RNA Translation Sites in Neurites in Response to Aβ1-42 Oligomers

Frontiers in Neuroscience, 2021
María Gamarra, María Gamarra, Maite Blanco-Urrejola, Maite Blanco-Urrejola, Maite Blanco-Urrejola, Andreia F. R. Batista, Andreia F. R. Batista, Andreia F. R. Batista, Josune Imaz, Jimena Baleriola, Jimena Baleriola, Jimena Baleriola   +11 more
doaj   +1 more source

CPEB3 low-complexity motif regulates local protein synthesis via protein-protein interactions in neuronal ribonucleoprotein granules. [PDF]

Proc Natl Acad Sci U S A, 2023
Ford L, Asok A, Tripp AD, Parro C, Fitzpatrick M, de Solis CA, Chen PY, Shafiian N, Fioriti L, Soni RK, Kandel ER.   +10 more
europepmc   +1 more source

Coming together to define membrane contact sites. [PDF]

, 2019
Close proximities between organelles have been described for decades. However, only recently a specific field dealing with organelle communication at membrane contact sites has gained wide acceptance, attracting scientists from multiple areas of cell ...
De Matteis, Maria Antonietta, Emr, Scott, Giordano, Francesca, Hajnóczky, György, Kornmann, Benoît, Lackner, Laura L., Levine, Tim P., Pellegrini, Luca, Reinisch, Karin, Rizzuto, Rosario, Schuldiner, Maya, Scorrano, Luca, Simmen, Thomas, Stenmark, Harald, Ungermann, Christian   +14 more
core   +7 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis

Nature Communications
Motoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular connections.
Abdolhossein Zare, Saeede Salehi, Jakob Bader, Cornelius Schneider, Utz Fischer, Alexander Veh, Panagiota Arampatzi, Matthias Mann, Michael Briese, Michael Sendtner   +9 more
doaj   +1 more source

Active presynaptic ribosomes in the mammalian brain, and altered transmitter release after protein synthesis inhibition

eLife, 2018
Presynaptic neuronal activity requires the localization of thousands of proteins that are typically synthesized in the soma and transported to nerve terminals.
Matthew S Scarnati, Rahul Kataria, Mohana Biswas, Kenneth G Paradiso   +3 more
doaj   +1 more source

Presynaptic FMRP and local protein synthesis support structural and functional plasticity of glutamatergic axon terminals. [PDF]

Neuron, 2022
Monday HR, Kharod SC, Yoon YJ, Singer RH, Castillo PE.   +4 more
europepmc   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Cloning of cDNA Encoding GRA1 Protein of Tachyzoite Toxoplasma Gondii Local Isolate

Indonesian Journal of Biotechnology, 2005
Gene encoding GRA1 protein is potent DNA-vaccine candidate against toxoplasmosis. The aim of the research was to clone the gene encoding GRA1 protein of tachyzoite Toxoplasma gondii local isolate by DNA recombinant technology.
Erma Sulistyaningsih, Sukarti Moeljopawiro, Jarot Subandono, Wayan T. Artama   +3 more
doaj   +1 more source

The prevalence and specificity of local protein synthesis during neuronal synaptic plasticity. [PDF]

Sci Adv, 2021
Sun C, Nold A, Fusco CM, Rangaraju V, Tchumatchenko T, Heilemann M, Schuman EM.   +6 more
europepmc   +1 more source