Results 71 to 80 of about 11,319,078 (248)

β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X

Cell Reports, 2017
Synaptic protein synthesis is essential for modification of the brain by experience and is aberrant in several genetically defined disorders, notably fragile X (FX), a heritable cause of autism and intellectual disability.
Laura J. Stoppel, Benjamin D. Auerbach, Rebecca K. Senter, Anthony R. Preza, Robert J. Lefkowitz, Mark F. Bear   +5 more
doaj   +1 more source

Optimal localization patterns in bacterial protein synthesis [PDF]

Physical Review E, 2018
In $\textit{Escherichia coli}$ bacterium, the molecular compounds involved in protein synthesis, messenger RNAs (mRNAs) and ribosomes, show marked intracellular localization patterns. Yet a quantitative understanding of the physical principles which would allow one to control protein synthesis by designing, bioengineering, and optimizing these ...
Nguyen, Jacky, Castellana, Michele
openaire   +4 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Arginine depletion by arginine deiminase does not affect whole protein metabolism or muscle fractional protein synthesis rate in mice.

PLoS ONE, 2015
Due to the absolute need for arginine that certain cancer cells have, arginine depletion is a therapy in clinical trials to treat several types of cancers.
Juan C Marini, Inka Cajo Didelija
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Actin mRNA localizes in the absence of protein synthesis. [PDF]

The Journal of cell biology, 1990
Actin mRNA is localized in chicken embryo fibroblasts to the distal regions of leading lamellae, but not within the ruffling edges. In this investigation we have addressed the role of actin translation in this process. The translocation of actin mRNA to the cell periphery was studied by monitoring the distribution of actin mRNA in cells during ...
Sundell, Cynthia L., Singer, Robert H.
openaire   +3 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Translação local de mRNAs em sindrome de Down [PDF]

, 2011
Mestrado em Biologia AplicadaO Síndrome de Down (DS) é a causa genética mais frequente de atraso mental. À semelhança de outros síndromes em que ocorrem deficiências em termos de memória e aprendizagem, as anomalias em especial ao nível das espinhas ...
Rodrigues, Carina Teresa dos Santos
core  

Locally synthesized glycyl aminoacyl-tRNA synthetase is important for local translation in neurons

Life Science Alliance
A key component of the translation machinery, the tRNA Gly -charging enzyme, is shown for the first time to contribute to local protein synthesis in neuronal extensions. Regulation of gene expression is essential for neuronal development and function.
Tyler Brent de Leon, Adi Golani-Armon, Bar Cohen, Yoav S Arava   +3 more
doaj   +1 more source

On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons

Cell Reports, 2019
Summary: Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far away from neuronal cell bodies.
Toshiaki Shigeoka, Max Koppers, Hovy Ho-Wai Wong, Julie Qiaojin Lin, Roberta Cagnetta, Asha Dwivedy, Janaina de Freitas Nascimento, Francesca W. van Tartwijk, Florian Ströhl, Jean-Michel Cioni, Julia Schaeffer, Mark Carrington, Clemens F. Kaminski, Hosung Jung, William A. Harris, Christine E. Holt   +15 more
doaj   +1 more source