Results 71 to 80 of about 7,662,913 (346)
Production, 2006 Neste trabalho, foi desenvolvida uma nova heurística de localização-alocação (HLA) para problemas de localização de facilidades (facility). Em tais problemas a questão central é localizar um objeto ou mais objetos, que são chamados de facilidades, e ...
Reinaldo Gen Ichiro Arakaki +1 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Journal of Intelligent Systems, 2019 In this research, different optimization models are developed to solve the preventive maintenance (PM) optimization problem in a maintainable multi-state series–parallel system.
Maatouk Imane +3 more
doaj +1 more source
An Improved SPEA2 Algorithm with Local Search for Multi-Objective Investment Decision-Making
Applied Sciences, 2019 Enterprise investment decision-making should not only consider investment profits, but also investment risks, which is a complex nonlinear multi-objective optimization problem.
Xi Liu, Dan Zhang
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Distributed localized bi-objective search [PDF]
European Journal of Operational Research, 2014 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Derbel, Bilel +3 more
openaire +4 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Two Efficient Local Search Algorithms for Maximum Weight Clique Problem
AAAI Conference on Artificial Intelligence, 2016 The Maximum Weight Clique problem (MWCP) is an important generalization of the Maximum Clique problem with wide applications. This paper introduces two heuristics and develops two local search algorithms for MWCP.
Yiyuan Wang, Shaowei Cai, Minghao Yin
semanticscholar +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source