Results 101 to 110 of about 10,866,611 (334)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Multi-Stage Sensitivity Analysis of the Energy Demand for the Cooling of Grain Warehouses in Cold Regions of China

Agriculture
The early design parameters exert a considerable influence on the cooling energy demand of a granary building in operation. In order to investigate the impact of various parameters on energy use, a grain warehouse energy model was constructed using the ...
Hua Zhang, Junya Ye, Kunming Li, Shujie Niu, Xiao Liu   +4 more
doaj   +1 more source

Growth grammars simulating trees – an extension of L-systems incorporating local variables and sensitivity.

Silva Fennica, 1997
The rule-based formal language of "stochastic sensitive growth grammars" was designed to describe algorithmically the changing morphology of forest trees during their lifetime under the impact of endogenous and exogenous factors, and to generate 3-D ...
Kurth, Winfried, Sloboda, Branislav
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Sufficiency of Local Feedback for Sensor-Actuator Network-Based Control Systems with Distance Sensitivity Properties

Journal of Sensor and Actuator Networks, 2013
Timely dissemination of required state information poses a significant challenge in the design of distributed sensor/actuator network-based control systems.
Vinod Kulathumani, Bryan Lemon
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Goodness of fit tests in terms of local levels with special emphasis on higher criticism tests

, 2016
Instead of defining goodness of fit (GOF) tests in terms of their test statistics, we present an alternative method by introducing the concept of local levels, which indicate high or low local sensitivity of a test.
Finner, Helmut, Gontscharuk, Veronika, Landwehr, Sandra   +2 more
core   +1 more source

Efficient computation of spaced seeds

BMC Research Notes, 2012
Background The most frequently used tools in bioinformatics are those searching for similarities, or local alignments, between biological sequences. Since the exact dynamic programming algorithm is quadratic, linear-time heuristics such as BLAST are used.
Ilie Silvana
doaj   +1 more source

Neighborhood-Based Local Sensitivity [PDF]

, 2007
We introduce a nonparametric model for sensitivity estimation which relies on generating points similar to the prediction point using its knearest neighbors. Unlike most previous work, the sampled points differ simultaneously in multiple dimensions from the prediction point in a manner dependent on the local density.
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source