Results 71 to 80 of about 10,866,611 (334)
A spatial model of the plant circadian clock reveals design principles for coordinated timing
Molecular Systems Biology, 2022 Individual plant cells possess a genetic network, the circadian clock, that times internal processes to the day‐night cycle. Mathematical models of the clock are typically either “whole‐plant” that ignore tissue or cell type‐specific clock behavior, or ...
Mark Greenwood +2 more
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Flow-Sensitive Fault Localization [PDF]
, 2013 Identifying the cause of an error is often the most time-consuming part in program debugging. Fault localization techniques can help to automate this task. Particularly promising are static proof-based techniques that rely on an encoding of error traces into trace formulas. By identifying irrelevant portions of the trace formula, the possible causes of
Jürgen Christ +3 more
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Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Learning locality-sensitive bucketing functions
BioinformaticsAbstract Motivation Many tasks in sequence analysis ask to identify biologically related sequences in a large set. The edit distance, being a sensible model for both evolution and sequencing error, is widely used in these tasks as a measure.
Xin Yuan +4 more
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Near-Optimal Euclidean Locality-Sensitive Orderings
, 2023 $ \newcommand{\Re}{\mathbb{R}} \newcommand{\reals}{\mathbb{R}} \newcommand{\SetX}{\mathsf{X}} \newcommand{\rad}{r} \newcommand{\Eps}{\Mh{\mathcal{E}}} \newcommand{\p}{\Mh{p}} \newcommand{\q}{\Mh{q}} \newcommand{\Mh}[1]{#1} \newcommand{\query}{q} \newcommand{\eps}{\varepsilon} \newcommand{\VorX}[1]{\mathcal{V} \pth{#1}} \newcommand{\Polygon}{\mathsf{P}}
Gao, Zhimeng, Har-Peled, Sariel
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Sensors, 2017 We derived an analytical expression for a resonant-mode based bi-layered cantilever with distributed mass load. The behavior of mode of vibration, nodal position, frequency shift, as well as sensitivity under different mass load distributions was ...
Kewei Zhang, Qianke Zhu, Zhe Chen
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Locality-sensitive hashing of curves
, 2017 Proc.
Driemel, Anne, SILVESTRI, FRANCESCO
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source