Results 81 to 90 of about 10,866,611 (334)

Local Wisdom, Environmental Sensitivity and Disaster Anticipation in Improving Social Balance of Students in Junior High Schools

open access: yesJurnal Teknologi Pendidikan
This study aims to analyze the influence of local wisdom, environmental sensitivity, and disaster anticipation on social balance in Jember Regency. In this study, a social theory is used that underlies that local wisdom, environmental sensitivity, and ...
sukidin sukidin   +2 more
doaj   +1 more source

Partially parallel imaging with localized sensitivities (PILS) [PDF]

open access: yesMagnetic Resonance in Medicine, 2000
In this study a novel partially parallel acquisition method is presented, which can be used to accelerate image acquisition using an RF coil array for spatial encoding. In this technique, Parallel Imaging with Localized Sensitivities (PILS), it is assumed that the individual coils in the array have localized sensitivity patterns, in that their ...
Griswold, M.A.   +4 more
openaire   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Using adjoint sensitivity as a local structure function in variational data assimilation [PDF]

open access: yesNonlinear Processes in Geophysics, 2001
One approach recently proposed in order to improve the forecast of weather events, such as cyclogenesis, is to increase the number of observations in areas depending on the flow configuration.
G. Hello, F. Bouttier
doaj  

Local opposite orientation preferences in V1: fMRI sensitivity to fine-grained pattern information

open access: yesScientific Reports, 2017
The orientation of a visual grating can be decoded from human primary visual cortex (V1) using functional magnetic resonance imaging (fMRI) at conventional resolutions (2–3 mm voxel width, 3T scanner).
Arjen Alink   +3 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Demographic sensitivity inside the local authorities [PDF]

open access: yes
The knowledge of the administrated population it is not wll appreciated at local level by the Administrators (Majors, Councillors, Public Servants). The attention is more devoted to political items and the sensitivity for the numbers of the population is
Enrico Todisco   +1 more
core  

Scanning superconducting quantum interference device on a tip for magnetic imaging of nanoscale phenomena

open access: yes, 2012
We describe a new type of scanning probe microscope based on a superconducting quantum interference device (SQUID) that resides on the apex of a sharp tip. The SQUID-on-tip is glued to a quartz tuning fork which allows scanning at a tip-sample separation
Finkler, A.   +8 more
core   +1 more source

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