Results 51 to 60 of about 939,081 (265)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Results in EngineeringThis study investigates the local and global sensitivity of five critical durability parameters affecting concrete performance in chloride environments: concrete cover thickness (d), apparent chloride diffusion coefficient (Dₐₚₚ), surface chloride ...
Lingjie Wu +3 more
doaj +1 more source
Sensitivity Analysis of Axial Compressive Bearing Capacity of CFRP Concrete-filled Steel Tube
Renmin Zhujiang, 2021 The axial compressive bearing capacity of CFRP concrete-filled steel tube is related to many factors.Due to material manufacturing and use,these parameters are not a definite value.Based on this,this paper carries out the sensitivity analysis of axial ...
WU Jian +3 more
doaj
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Local Buckling Check and Sensitivity Analysis Based on J-lay
Shiyou jixie, 2018 In view of the limitation of the local buckling failure evaluation formula of J-lay based on the natural catenary model, the Winkler foundation modeling is introduced for improvement. The entire suspension section is divided into two sections.
Wang Shuai
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
SACR EPIDEMIC MODEL FOR THE SPREAD OF HEPATITIS B DISEASE BY CONSIDERING VERTICAL TRANSMISSION
BarekengHepatitis B is an infectious disease that causes inflammation of the liver due to infection with the Hepatitis B virus. Hepatitis B is divided into two phases: the acute phase and the chronic phase.
Yuni Yulida +4 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source