Results 91 to 100 of about 8,380,026 (270)

Emerging concepts and recent advances in basal cell carcinoma [version 1; referees: 2 approved]

F1000Research, 2017
Basal cell carcinoma (BCC) is the most common malignancy worldwide, arising from non-keratinizing cells within the basal layer of the epidermis. The incidence of BCC continues to rise annually, increasing the burden of management of these carcinomas and ...
Mariam Totonchy, David Leffell
doaj   +1 more source

Hedgehog Pathway Inhibition for the Treatment of Basal Cell Carcinoma

, 2019
Globally, basal cell carcinoma is the most commonly diagnosed cancer. While most cases are amenable to surgery, treatment options for advanced basal cell carcinoma, including locally advanced basal cell carcinoma and metastatic basal cell carcinoma, have
Gutzmer, Ralf, Solomon, James A.
core   +1 more source

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Locally advanced basal cell carcinoma of the face with surprising response to R-CHOP

, 2017
Treatment of choice for high risk basal cell carcinoma (BCC) of the face is Mohs micrographic surgery. Radiotherapy can be applied when surgery will result in cosmetic and/or functional morbidity.
Reyners, A. K.L.; id_orcid, Urgert, M. C., De Vijlder, H. C., Nijland, M.; id_orcid, Diercks, G. F.H.; id_orcid, Terra, J. B.   +5 more
core   +1 more source

Sclerodermiform basal cell carcinoma in an elderly woman

, 2023
The most commonly detected non-melacytic skin tumor in humans is "basal cell carcinoma". There are many clinical varieties of this tumor, some of which are quite rare.
Ekaterina V. Zadionchenko, Larisa I. Glebova   +1 more
core   +1 more source

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source

Treatment of progressive locally advanced and metastatic basal cell carcinoma after two lines of treatment with hedgehog inhibitors and anti-PD1. the role of sonidegib rechallenge

Treatment of progressive locally advanced and metastatic basal cell carcinoma after two lines of treatment with hedgehog inhibitors and anti-PD1: The role of sonidegib ...
Guida, S, Di Lella, G, Guida S., Ambrosio L., Zalaudek, I, Conforti C., Retrosi C., Pellacani, G, Giuffrida, R, Longo, C, Zalaudek I., Agozzino M., Di Lella G., di Meo N., Cantisani, C, Agozzino, M, Ambrosio, L, Conforti, C, Giuffrida R., Retrosi, C, Longo C., Lembo, S, Pellacani G., di Meo, N, Lembo S., Cantisani C., Cantisani, C., di Meo, N., Ambrosio, L., Di Lella, G., Longo, C., Pellacani, G., Zalaudek, I., Agozzino, M., Retrosi, C., Guida, S., Lembo, S., Conforti, C., Giuffrida, R.   +38 more
core   +1 more source

Predictive factors of response to vismodegib: a French study of 61 patients with multiple or locally advanced basal cell carcinoma

, 2022
International audienceVismodegib is indicated for the treatment of advanced or metastatic basal cell carcinoma (BCC).
Dreno, Brigitte, Isvy-Joubert, Anne, Juzot, Cécile, Knol, Anne-Chantal, Nguyen, Jean-Michel, Khammari, Amir   +5 more
core   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source